2-联苯-2-基-4,4-二甲基-4,5-二氢噁唑合成路线 （共 15 条）
反应条件
Oxonereg;; sodium hydroxide; 1,1,1-trifluoropropanone; sodium hydrogencarbonate 1) CH3CN, H2O, (Na2*EDTA), pH 7-7.5), RT, 2) MeOH, 12 h, reflux; Yield given. Multistep reaction;
参考文献
Yang, Dan; Yip, Yiu-Chung; Wang, Xue-Chao
Tetrahedron Letters, 1997 , vol. 38, # 40 p. 7083 - 7086
反应条件
1: 90 percent / DIBAL / diethyl ether / 21 h / Ambient temperature 2: 87 percent / H2 / Pd/C / ethanol / 21 h / 2585.7 Torr / Ambient temperature View Scheme
参考文献
Meyers, A. I.; Himmelsbach, Richard J.; Reuman, Michael
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4053 - 4058
反应条件
1: 90 percent / DIBAL / diethyl ether / 21 h / Ambient temperature 2: 1.) NCS; 2.) alumina / 1.) methylene chloride, room temp., 43h; 2.) 2h View Scheme
参考文献
Meyers, A. I.; Himmelsbach, Richard J.; Reuman, Michael
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4053 - 4058
反应条件
thionyl chloride in toluene
T=20°C; 48 h;
参考文献
Houlihan, William J.; Kelly, Lawrence; Pankuch, Jessica; Koletar, Judith; Brand, Leonard; Janowsky, Aaron; Kopajtic, Theresa A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4097 - 4109
反应条件
manganese (II) chloride in tetrahydrofuran
T=20°C; Substitution; Cross-coupling reaction; 24 h;
参考文献
Cahiez, Gerard; Lepifre, Franck; Ramiandrasoa, Parfait
Synthesis, 1999 , # 12 p. 2138 - 2144
反应条件
1: in diethyl ether
T=35°C; 1 h;
2: With water; ammonium chloride in diethyl ether
参考文献
Cetin, Fatma; Baris Senogul; Gezer, Sibel; Astley, Demet; Astley, Stephen T.
Journal of Organometallic Chemistry, 2004 , vol. 689, # 1 p. 154 - 157
反应条件
palladium diacetate in acetonitrile
0.166667 h; HeatingInert atmosphere;
参考文献
Yu, Wing-Yiu; Sit, Wing Nga; Zhou, Zhongyuan; Chan, Albert S.-C.
Organic Letters, 2009 , vol. 11, # 15 p. 3174 - 3177
反应条件
1: in diethyl ether
T=0°C; 0.5 h;
2: With water; ammonium chloride in diethyl ether
参考文献
Cetin, Fatma; Baris Senogul; Gezer, Sibel; Astley, Demet; Astley, Stephen T.
Journal of Organometallic Chemistry, 2004 , vol. 689, # 1 p. 154 - 157
反应条件
[rhodium(I)(carbonyl)2(acetylacetonate)] in chlorobenzene
T=140°C; 36 h;
参考文献
Lei, Zhi-Quan; Li, Hu; Li, Yang; Zhang, Xi-Sha; Chen, Kang; Wang, Xin; Sun, Jian; Shi, Zhang-Jie
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2690 - 2694
反应条件
1: 68 percent / CH2Cl2 / 24 h / 20 °C
2: 78 percent / SOCl2 / toluene / 48 h / 20 °C
View Scheme
参考文献
Houlihan, William J.; Kelly, Lawrence; Pankuch, Jessica; Koletar, Judith; Brand, Leonard; Janowsky, Aaron; Kopajtic, Theresa A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4097 - 4109
