2-(2-甲氧基苯基)-4,4-二甲基-2-噁唑啉合成路线 （共 54 条）
反应条件
1: 1.) Mg / 1.) THF, 80 deg C, 0.5 h, 2.) THF, 40 deg C, 5 h 2: 6 N aq. HCl / 60 h / Heating View Scheme
参考文献
Dorra, Michael; Gomann, Klaus; Guth, Michael; Kirmse, Wolfgang
Journal of Physical Organic Chemistry, 1996 , vol. 9, # 9 p. 598 - 610
反应条件
sodium hydroxide; sodium hypochlorite; tetra(n-butyl)ammonium hydrogensulfate 1.) ethyl acetate, water, room temp.; 2.) CH3OH, 5 h, room temp.; Yield given. Multistep reaction;
参考文献
Levin, Jeremy I.; Weinreb, Steven M.
Tetrahedron Letters, 1982 , vol. 23, # 23 p. 2347 - 2350
反应条件
1: 79 percent / tetrahydrofuran / Ambient temperature 2: H2SO4 / methanol / 4 h / Heating 3: 4.5 N HCl / Heating View Scheme
参考文献
VanAtten, Mary K.; Ensinger, Carol L.; Chiu, Andrew T.; McCall, Dale E.; Nguyen, Tam T.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 3985 - 3992
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 88 percent / 4.5 N aq. HCl / 12 h / Heating View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 98 percent / tetrahydrofuran 2: 1.) CH3I, 2.) NaBH4 / 1.) EtNO2, 2.) EtOH 3: pyridinium chlorochromate, pyridine / CH2Cl2 View Scheme
参考文献
Nate; Sekine; Honma; Nakai; Wada; Takeda; Yabana; Nagao
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1953 - 1968
反应条件
1: tetrahydrofuran / Ambient temperature 2: H2SO4 / methanol / 4 h / Heating 3: 4.5 N HCl / Heating View Scheme
参考文献
VanAtten, Mary K.; Ensinger, Carol L.; Chiu, Andrew T.; McCall, Dale E.; Nguyen, Tam T.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 3985 - 3992
参考文献
Dorra, Michael; Gomann, Klaus; Guth, Michael; Kirmse, Wolfgang
Journal of Physical Organic Chemistry, 1996 , vol. 9, # 9 p. 598 - 610
反应条件
magnesium 1.) THF, 80 deg C, 0.5 h, 2.) THF, 40 deg C, 5 h; Yield givenMultistep reaction;
参考文献
Ohkawa, Takehiko; Zenkoh, Tatsuya; Tomita, Masayuki; Hosogai, Naomi; Hemmi, Keiji; Tanaka, Hirokazu; Setoi, Hiroyuki
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 4 p. 501 - 510
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 3: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 88 percent / 4.5 N aq. HCl / 12 h / Heating 3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 4: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
