3-乙氧基-2-丁烯酸乙酯合成路线 （共 6 条）
参考文献
Sugiyama, Tomohito; Yamakoshi, Hideyuki; Nojima, Masatomo
Journal of Organic Chemistry, 1993 , vol. 58, # 16 p. 4211 - 4218
反应条件
tetrachloromethane; N-bromosuccinmide
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 69, p. 729,741
Journal of the American Chemical Society, , vol. 73, p. 1054,1058
反应条件
1: 90 percent / N-bromo-succinimide, benzoylperoxide / CCl4 / 3 h / Heating
2: 70 percent / H2O / 12 h / Ambient temperature
View Scheme
参考文献
Kochhar; Carson; Clouser; et al.
Tetrahedron Letters, 1984 , vol. 25, # 18 p. 1871 - 1874
反应条件
(i) KOtBu, DMF, (ii) aq. HCl; Multistep reaction;
参考文献
Thomae GmbH
Patent: FR2254320DE2450991 , 19751976 ;
Chem.Abstr., 1976 , vol. 85, # 32630
反应条件
1: (E)-3-ethoxy-crotonic acid ethyl ester With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-70°C; 2.5 h;
2: (1S,2R,4R,SS)-7,7-dimethyl-N-(phenylmethylene)-2-(trimethylsilyloxy)bicyclo[2.2.1]heptane-1-methanesulfinamide in tetrahydrofuran; hexane
T=-30°C; 3.5 h;
3: With hydrogenchloride in ethanol; dichloromethane
T=20°C; 24 h; Title compound not separated from byproducts;
参考文献
Kaw, Robert
Tetrahedron, 2001 , vol. 57, # 39 p. 8385 - 8390
反应条件
1: 94 percent / LDA / tetrahydrofuran / -78 - 20 °C
2: 79 percent / Et2AlCl / CH2Cl2; hexane / 18 h / -78 - 25 °C
View Scheme
参考文献
Koegl; de Bruin
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 729,741
Full Text Show Details
Reid; Ruby
Journal of the American Chemical Society, 1951 , vol. 73, p. 1054,1058
