1: 4-bromo-2-fluoro-1-phenyl-benzene With n-butyllithium in tetrahydrofuran T=-78°C; 1.16667 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78 - 20°C; 5 h;

potassium carbonate in isopropyl alcohol T=80°C; Suzuki coupling; 3 h;

Yield given. Multistep reaction;

1.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / |Inert atmosphere 1.2: 1 h / 20 °C / |Inert atmosphere 2.1: 1,1,2,2-tetramethylethylene; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol / 0.73 h / 20 °C View Scheme