1-(5,6,7,8-四氢萘-1-基)哌嗪合成路线 （共 3 条）
反应条件
sodium carbonate in butan-1-ol
68 h; Heating/reflux;
参考文献
Abbott Laboratories
Patent: US6346622 B1, 2002 ;
Location in patent: Page column 7 ;
反应条件
toluene-4-sulfonic acid in chlorobenzene
参考文献
Kuipers, Wilma; Wijngaarden, Ineke van; Kruse, Chris G.; Amstel, Marian ter Horst-van; Tulp, Martin Th. M.; IJzerman, Adriaan P.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1942 - 1954
反应条件
1: Fe, aq. HCl / ethanol
2: p-TsOH / chlorobenzene
View Scheme
参考文献
Kuipers, Wilma; Wijngaarden, Ineke van; Kruse, Chris G.; Amstel, Marian ter Horst-van; Tulp, Martin Th. M.; IJzerman, Adriaan P.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1942 - 1954
