吡唑[1,5-A]嘧啶-5,7(4H,6H)-二酮合成路线 （共 5 条）
反应条件
sodium ethanolate in ethanol T=80°C; 16 h; Inert atmosphere;
参考文献
SCHERING CORPORATION; MENG, Zhaoyang; REDDY, Panduranga Adulla, P.; SIDDIQUI, M. Arshad; MANDAL, Amit, K.; LIU, Duan; ZHAO, Lianyun; MCRINER, Andrew
Patent: WO2012/27234 A1, 2012 ;
Location in patent: Page/Page column 39; 40 ;
WO 2012/027234 A1
反应条件
ethanol; sodium Reflux;
参考文献
ACS Medicinal Chemistry Letters, , vol. 1, # 5 p. 204 - 208
反应条件
1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / 0 - 60 °C / Inert atmosphere 2: ammonium hydroxide / 20 - 85 °C / Sealed tube View Scheme
参考文献
SCHERING CORPORATION; MENG, Zhaoyang; REDDY, Panduranga Adulla P.; SIDDIQUI, M. Arshad
Patent: WO2012/47569 A1, 2012 ;
WO 2012/047569 A1
反应条件
N,N-dimethyl-aniline; trichlorophosphate T=0 - 60°C; 16 h; Inert atmosphere;
参考文献
SCHERING CORPORATION; MENG, Zhaoyang; REDDY, Panduranga Adulla, P.; SIDDIQUI, M. Arshad; MANDAL, Amit, K.; LIU, Duan; ZHAO, Lianyun; MCRINER, Andrew
Patent: WO2012/27234 A1, 2012 ;
Location in patent: Page/Page column 40 ;
WO 2012/027234 A1
反应条件
1: trichlorophosphate; N,N-dimethyl-aniline / 18 h / |Reflux 2: N-bromosuccinmide / chloroform / 1 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 22 p. 10312 - 10313
