2’-甲基联苯-4-甲酸合成路线 （共 21 条）
反应条件
disodium hydrogenphosphate; Pd(OAc)2(2-amino-4,6-dihydroxypyrimidine disodium salt)2 in water T=120°C; Suzuki-Miyaura coupling; 0.166667 h; Microwave irradiation;
参考文献
Chalker, Justin M.; Wood, Charlotte S. C.; Davis, Benjamin G.
Journal of the American Chemical Society, 2009 , vol. 131, # 45 p. 16346 - 16347
反应条件
palladium diacetate; sodium carbonate in water T=150°C; Suzuki coupling; Microwave irradiation;
参考文献
SIENA BIOTECH S.P.A.
Patent: WO2006/8133 A2, 2006 ;
Location in patent: Page/Page column 20-21 ;
WO 2006/008133 A2
反应条件
tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=80°C; 48 h;
参考文献
Homsi, Fadi; Nozaki, Kyoko; Hiyama, Tamejiro
Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5869 - 5872
反应条件
potassium fluoride; trifuran-2-yl-phosphane; palladium diacetate in N,N-dimethyl-formamide T=120°C; 44 h;
参考文献
Homsi, Fadi; Hosoi, Kazushi; Nozaki, Kyoko; Hiyama, Tamejiro
Journal of Organometallic Chemistry, 2001 , vol. 624, # 1-2 p. 208 - 216
反应条件
hydrogenchloride; sodium hydroxide; sodium carbonate in water; toluene
参考文献
Halazy, Serge; Quattropani, Anna; Scheer, Alexander; Schwarz, Mattias; Thomas, Russell; Baxter, Antony
Patent: US2003/212012 A1, 2003 ;
反应条件
sodium chlorite; sodium dihydrogenphosphate in 2-methyl-but-2-ene; water; tert-butyl alcohol T=20°C;
参考文献
EP1577302 A1, ;
Page/Page column 101 ;
反应条件
potassium fluoride; potassium carbonate in water T=100°C; Suzuki-Miyaura coupling; 5 h;
参考文献
Bernini, Roberta; Cacchi, Sandro; Fabrizi, Giancarlo; Forte, Giovanni; Petrucci, Francesco; Prastaro, Alessandro; Niembro, Sandra; Shafir, Alexandr; Vallribera, Adelina
Green Chemistry, 2010 , vol. 12, # 1 p. 150 - 158
反应条件
[(P{(NC5H10)(C6H11)2})2Pd(Cl)2] in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; 0.25 h; In air;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Chemistry - A European Journal, 2010 , vol. 16, # 36 p. 11072 - 11081
反应条件
1.1: Mg / tetrahydrofuran 1.2: 35 percent / tetrahydrofuran / 20 °C 2.1: 82 percent / KF; tri(2-furyl)phosphine / Pd(OAc)2 / dimethylformamide / 44 h / 120 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 624, # 1-2 p. 208 - 216
反应条件
1: 61 percent / CuF2*2H2O / diethyl ether / 20 °C 2: 93 percent / TBAF / Pd(PPh3)4 / tetrahydrofuran / 48 h / 80 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 624, # 1-2 p. 208 - 216
