4-乙酰基-4'-甲基联苯合成路线 （共 60 条）
反应条件
1: (4-methylphenyl)trichlorogermane With ammonium hydroxide T=20°C; 1 h; 2: para-bromoacetophenone With sodium hydroxide; palladium diacetate in 1,4-dioxane; water 1.5 h; Heating; Further stages.;
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 7 p. 1025 - 1027
反应条件
hydrogenchloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
参考文献
Bayer Aktiengesellschaft
Patent: EP1031349 A1, 2000 ;
反应条件
CM-phos; H2O4P(1-)*3K(1+); palladium diacetate; triethylamine in tert-butyl alcohol T=20 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chow, Wing Kin; So, Chau Ming; Lau, Chak Po; Kwong, Fuk Yee
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5109 - 5112
反应条件
tris-(dibenzylideneacetone)dipalladium(0); sodium hydrogencarbonate; tri-cyclo-hexyl-phosphine in N,N-dimethyl acetamide T=60°C; P=775.743 Torr; 12 h;
参考文献
Saini, Vaneet; Liao, Longyan; Wang, Qiaofeng; Jana, Ranjan; Sigman, Matthew S.
Organic Letters, 2013 , vol. 15, # 19 p. 5008 - 5011
反应条件
tris(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)(4'-ethylphenyl)tin; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; N,N-dimethyl-formamide T=80°C; Stille coupling; 8 h;
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8341 - 8349
反应条件
1: 1)Mg / 1) ether, 2) THF, RT, overnight 2: 1)SbF3 / 1) - 70 deg C, 2) 2h, RT, 3) 2h, 100 deg C 3: 73 percent / KF / (η3-C3H5PdCl)2 / 1,2-dimethoxy-ethane / 1 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 48, # 11 p. 2113 - 2126
反应条件
tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; silver(l) oxide in tetrahydrofuran T=70°C; Hiyama-type coupling; 18 h;
参考文献
Napier, Spencer; Marcuccio, Sebastian M.; Tye, Heather; Whittaker, Mark
Tetrahedron Letters, 2008 , vol. 49, # 24 p. 3939 - 3942
反应条件
1: 4'-iodoacetophenone With lithium chloride in N,N-dimethyl-formamide T=80°C; 2: 1-(iodo)-4-methylbenzene With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=80°C; 3 h; Inert atmosphere;
参考文献
Papoian, Vardan; Minehan, Thomas
Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7376 - 7379
反应条件
Br(1-)*C24H31BrN5O6Pd(1+); sodium hydroxide in water T=160°C; Hiyama coupling; 2 h; Sealed tube;
参考文献
Ines, Blanca; Moure, Maria Jesus; SanMartin, Raul; Herrero, Maria Teresa; Moreno, Isabel; Dominguez, Esther
Arkivoc, 2011 , vol. 2011, # 3 p. 191 - 199
反应条件
1: trifluoro(p-tolyl)silane With tetrabutyl ammonium fluoride; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tert-butyl alcohol T=20°C; Hiyama cross-coupling reaction; 0.0833333 h; Inert atmosphereSealed vial; 2: para-chloroacetophenone in tert-butyl alcohol T=60°C; Hiyama cross-coupling reaction; Inert atmosphereSealed vial;
参考文献
Molander, Gary A.; Iannazzo, Laura
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9182 - 9187
