4-乙酰基-4'-甲基联苯合成路线 （共 60 条）
反应条件
tetrabutylammomium bromide; caesium carbonate; triphenylphosphine; palladium dichloride in N,N-dimethyl acetamide T=90°C; 1 h;
参考文献
Rao, Maddali L.N.; Jadhav, Deepak N.; Banerjee, Debasis
Tetrahedron, 2008 , vol. 64, # 24 p. 5762 - 5772
反应条件
potassium fluoride; bis(η3-allyl-μ-chloropalladium(II)) in ethylene glycol dimethyl ether T=100°C; 1 h;
参考文献
Hatanaka, Yasuo; Fukushima, Satoshi; Hiyama, Tamejiro
Tetrahedron, 1992 , vol. 48, # 11 p. 2113 - 2126
反应条件
1: p-Me-C6H4-X, X = lithium or magnesium halide With titanium tetraethoxide in tetrahydrofuran T=0°C; 2: para-bromoacetophenone With 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=-20°C; 6 h; Further stages.;
参考文献
Manolikakes, Georg; Dastbaravardeh, Navid; Knochel, Paul
Synlett, 2007 , # 13 p. 2077 - 2080
反应条件
palladium diacetate in ethanol T=95°C; 0.25 h; microwave irradiation;
参考文献
Kabalka, George W.; Zhou, Li-Li; Naravane, Abhijit
Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6887 - 6889
反应条件
1: hexa-4-tolyl-cyclotrisiloxane With potassium hydroxide in 1,4-dioxane; water Heating; 2: para-bromoacetophenone With palladium diacetate in 1,4-dioxane; water 0.5 h; Heating; Further stages.;
参考文献
Endo, Mayuko; Sakurai, Tomoyuki; Ojima, Satoshi; Katayama, Takako; Unno, Masafumi; Matsumoto, Hideyuki; Kowase, Susumu; Sano, Hiroshi; Kosugi, Masanori; Fugami, Keigo
Synlett, 2007 , # 5 p. 749 - 752
反应条件
tripotassium phosphate monohydrate; palladium diacetate; α,α'-bis(di-t-butylphosphino)-o-xylene in tetrahydrofuran T=20°C; Suzuki-Miyaura cross-coupling reaction; 48 h; Inert atmosphere;
参考文献
McNulty, James; Nair, Jerald J.; Sliwinski, Marcin; Robertson, Al J.
Tetrahedron Letters, 2009 , vol. 50, # 20 p. 2342 - 2346
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide in neat (no solvent) T=20°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
morpholine; C31H45Cl2N3OPd; caesium carbonate in water T=110°C; Suzuki-Miyaura Coupling; 12 h; Inert atmosphere;
参考文献
Wang, Zhan-Yong; Ma, Qin-Na; Li, Ren-Hao; Shao, Li-Xiong
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 45 p. 7899 - 7906
反应条件
tri-tert-butyl phosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in ethylene glycol dimethyl ether; hexane T=20°C;
参考文献
Saeki, Tomoyuki; Matsunaga, Tadafumi; Son, Eun-Cheol; Tamao, Kohei
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1689 - 1692
反应条件
sodium hydroxide; tetrabutylammomium bromide; 4,4'-dichlorobenzophenone oxime-derived palladacycle T=120°C; Hiyama coupling; P=7500.6 Torr; 0.25 h; microwave irradiation;
参考文献
Alacid, Emilio; Najera, Carmen
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 7-8 p. 945 - 952
