4,6-二苯基-[2,2]联吡啶合成路线 （共 17 条）
反应条件
n-butyllithium in tetrahydrofuran
T=0°C; 1 h;
参考文献
Palacios, Francisco; Ochoa De Retana, Ana M. Ochoa; Oyarzabal, Julen
Tetrahedron Letters, 1996 , vol. 37, # 26 p. 4577 - 4580
反应条件
pyrrolidine
T=120°C; 0.25 h; microwave irradiation;
参考文献
Sainz, Yolanda Fernandez; Raw, Steven A.; Taylor, Richard J. K.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10086 - 10095
反应条件
sodium hydroxide in 1,4-dioxane
T=75°C; 2.5 h;
参考文献
Lau, Chan; Tsui, Gavin Chit; Lautens, Mark
Synthesis, 2011 , # 23 art. no. Z92211SS, p. 3908 - 3914
反应条件
1: With tetrakis(triphenylphosphine) palladium(0); sodium acetate in N,N-dimethyl-formamide
T=80°C; 12 h; Inert atmosphere;
2: in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
He, Zhi; Dobrovolsky, Dennis; Trinchera, Piera; Yudin, Andrei K.
Organic Letters, 2013 , vol. 15, # 2 p. 334 - 337
反应条件
lithium diisopropyl amide in tetrahydrofuran
参考文献
Palacios, Francisco; Ochoa De Retana, Ana M. Ochoa; Oyarzabal, Julen
Tetrahedron Letters, 1996 , vol. 37, # 26 p. 4577 - 4580
反应条件
ammonium acetate in methanol
T=80°C; Kroehnke synthesis;
参考文献
Basnet, Arjun; Thapa, Pritam; Karki, Radha; Na, Younghwa; Jahng, Yurngdong; Jeong, Byeong-Seon; Jeong, Tae Cheon; Lee, Chong-Soon; Lee, Eung-Seok
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 13 p. 4351 - 4359
反应条件
1.1: magnesium sulfate / dichloromethane / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); sodium acetate / N,N-dimethyl-formamide / 12 h / 80 °C / |Inert atmosphere
2.2: air / 12 h / 80 °C
View Scheme
参考文献
He, Zhi; Dobrovolsky, Dennis; Trinchera, Piera; Yudin, Andrei K.
Organic Letters, 2013 , vol. 15, # 2 p. 334 - 337
反应条件
pyrrolidine
T=150°C; 1 h; microwave irradiation;
参考文献
Sainz, Yolanda Fernandez; Raw, Steven A.; Taylor, Richard J. K.
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10086 - 10095
反应条件
1: NaOH / 0.17 h
2: 2.66 g / NH4OAc / acetic acid / 2 h / Heating
View Scheme
参考文献
Cave, Gareth W. V.; Raston, Colin L.
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 24 p. 3258 - 3264
反应条件
1: 1.) LDA / tetrahydrofuran
2: 87 percent / 1.) BuLi / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Palacios, Francisco; Ochoa De Retana, Ana M. Ochoa; Oyarzabal, Julen
Tetrahedron Letters, 1996 , vol. 37, # 26 p. 4577 - 4580
