11-(1-哌嗪基)二苯并[B,F][1,4]硫氮杂卓合成路线 （共 21 条）
反应条件
sodium hydroxide in water; toluene T=70°C; 0.75 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/73360 A1, 2006 ;
Location in patent: Page/Page column 10-11 ;
WO 2006/073360 A1
反应条件
1: With hydrogenchloride; methanol T=20°C; 24 h; 2: With sodium carbonate pH=9;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/69356 A1, 2010 ;
Location in patent: Page/Page column 26 ;
US 20100069356 A1
反应条件
titanium tetrachloride in 1,4-dioxane; toluene T=50 - 100°C;
参考文献
WO2005/63254 A2, ;
Page/Page column 59-60 ;
WO 2005/063254 A2
反应条件
in o-xylene T=20 - 142°C; 40 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2007/62338 A2, 2007 ;
Location in patent: Page/Page column 16-17 ;
WO 2007/062338 A2
反应条件
hydrogenchloride in ethanol; toluene
参考文献
IMPERIAL CHEMICAL INDUSTRIES PLC
Patent: EP282236 B1, 1991 ;
反应条件
T=170°C; 5 h; Heating / reflux;
参考文献
UNION QUIMICO-FARMACEUTICA S.A.
Patent: WO2006/94549 A1, 2006 ;
Location in patent: Page/Page column 16-17 ;
参考文献
WO2006/135544 A1, ;
Page/Page column 11 ;
反应条件
1: With phosphorus pentoxide; trichlorophosphate 12 h; Heating / reflux; 2: With water 3: With sodium hydroxide in water Product distribution / selectivity;
参考文献
WO2005/12274 A1, ;
Page/Page column 6-8; 12 ;
反应条件
1: sodium hydroxide / dimethyl sulfoxide / 80 °C 2: hydrogen / methanol / 4137.29 Torr 3: sodium carbonate / tetrahydrofuran; water 4: PPA / 100 °C 5: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane 6: triethylamine / tetrahydrofuran; toluene View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
1: sodium hydroxide / dimethyl sulfoxide / 80 °C 2: hydrogen / methanol / 4137.29 Torr 3: sodium carbonate / tetrahydrofuran; water 4: PPA / 100 °C 5: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane 6: triethylamine / tetrahydrofuran; toluene View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
