4-(2-甲基-1,3-二氧戊环-2-基)-1-丁醇合成路线 （共 4 条）
反应条件
1: pyridine / 18 h / Ambient temperature 2: 1.) K2CO3 / 1.) DMF, 120 deg C, 1 h, 2.) DMF, 120 deg C 3: HCl, MeOH / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 14 p. 2527 - 2534
反应条件
hydrogenchloride in tetrahydrofuran
Ambient temperature;
参考文献
Collins, Paul W.; Gasiecki, Alan F.; Perkins, Willam E.; Gullikson, Gary W.; Jones, Peter H.; Bauer, Raymond F.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1001 - 1006
反应条件
1: PDC / CH2Cl2 / 20 °C
2: LiOH*H2O / tetrahydrofuran / 20 °C
3: 89 percent / pTsOH / acetone / Heating
View Scheme
参考文献
Shindo, Mitsuru; Matsumoto, Kenji; Sato, Yusuke; Shishido, Kozo
Organic Letters, 2001 , vol. 3, # 13 p. 2029 - 2030
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane
T=-78 - 20°C; Swern oxidation;
参考文献
Backes, J. Rene; Koert, Ulrich
European Journal of Organic Chemistry, 2006 , # 12 p. 2777 - 2785
