6-硝基-2,3-二氢喹啉-4(1h)-酮合成路线 （共 4 条）
反应条件
nitric acid; acetic acid
T=0 - 20°C;
参考文献
Song, Jiangli; Jones, Lindsay M.; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Jantz, Adam; Johansen, Audra; Bayeh, Liela; Soeung, Victoria; Snyder, Lindsey K.; Lade Jr., Shawn D.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2801 - 2807
反应条件
sulfuric acid; nitric acid
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bolotina, L. A.; Lopatin, B. V.; Bekhli, A. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , p. 508 - 510
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 5 p. 671 - 673
反应条件
1.1: acetic acid / 0.33 h / 200 °C / |Microwave irradiation
1.2: 60 h / 70 °C
2.1: polyphosphoric acid / 3.5 h / 50 °C
3.1: nitric acid; acetic acid / 0 - 20 °C
View Scheme
参考文献
Song, Jiangli; Jones, Lindsay M.; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Jantz, Adam; Johansen, Audra; Bayeh, Liela; Soeung, Victoria; Snyder, Lindsey K.; Lade Jr., Shawn D.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2801 - 2807
反应条件
1: polyphosphoric acid / 3.5 h / 50 °C
2: nitric acid; acetic acid / 0 - 20 °C
View Scheme
参考文献
Song, Jiangli; Jones, Lindsay M.; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Jantz, Adam; Johansen, Audra; Bayeh, Liela; Soeung, Victoria; Snyder, Lindsey K.; Lade Jr., Shawn D.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2801 - 2807
