1.1: ozone / CH2Cl2; methanol / 2 h / -78 °C 1.2: 51 percent / dimethyl sulfide / CH2Cl2; methanol / -78 - 20 °C 2.1: sodium borohydride / ethanol; CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Borch, Richard F.; Liu, Jiwen; Schmidt, James P.; Marakovits, Joseph T.; Joswig, Carolyn; Gipp, Jerry J.; Mulcahy, R. Timothy
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2258 - 2265
1: With ozone in methanol; dichloromethane
T=-78°C; ozonization; 2 h;
2: With dimethylsulfide in methanol; dichloromethane
T=-78 - 20°C; Reduction; Further stages.;
参考文献
Borch, Richard F.; Liu, Jiwen; Schmidt, James P.; Marakovits, Joseph T.; Joswig, Carolyn; Gipp, Jerry J.; Mulcahy, R. Timothy
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2258 - 2265
