4-羟基-7-三氟甲基-3-喹啉羧酸合成路线 （共 6 条）
反应条件
lithium hydroxide hydrate in methanol T=0°C; 2.16667 h;
参考文献
Garudachari; Isloor, Arun M.; Satyanarayana; Fun, Hoong-Kun; Pavithra; Kulal, Ananda
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 422 - 432
反应条件
1: diphenyl ether / Heating 2: 2 N NaOH / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 25 p. 4918 - 4926
反应条件
2: diphenyl ether 3: aqueous NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 69, p. 371,373
反应条件
1: diphenyl ether / 1 h / Heating 2: POCl3 / 1.17 h / 100 - 110 °C View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
反应条件
1: 260 °C
2: phosphorus (V)-chloride; phosphoryl chloride / 130 °C
View Scheme
参考文献
Snyder et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 371,373
