2(R)-乙酰基硫代-苯丙酸合成路线 （共 9 条）
反应条件
in DMF (N,N-dimethyl-formamide) T=20°C; 20 h;
参考文献
BIOMEP INC.
Patent: WO2004/50620 A2, 2004 ;
Location in patent: Page 38-39 ;
反应条件
in N,N-dimethyl-formamide Ambient temperature;
参考文献
Coric, Pascale; Turcaud, Serge; Meudal, Herve; Roques, Bernard Pierre; Fournie-Zaluski, Marie-Claude
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1210 - 1219
反应条件
in methanol 12 h; Ambient temperature;
参考文献
Spaltenstein; Leban; Furfine
Tetrahedron Letters, 1993 , vol. 34, # 9 p. 1457 - 1460
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran 1.) 0 deg C, 15 min; 2.) 0 deg C; 15 min without cooling; Title compound not separated from byproducts;
参考文献
Strijtveen, Bert; Kellog, Richard M.
Recueil des Travaux Chimiques des Pays-Bas, 1987 , vol. 106, # 10 p. 539 - 542
反应条件
1: 88 percent / 48percent aq. HBr, aq. NaNO2 / 2 h / 0 °C 2: 98 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 6 p. 1210 - 1219
反应条件
1: DMAP / CH2Cl2 2: aq. LiOH; H2O2 / tetrahydrofuran 3: (COCl)2 / dimethylformamide; CH2Cl2 / 0 °C 4: pyridine / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 17 p. 2549 - 2554
反应条件
in N,N-dimethyl-formamide T=20°C;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 11 p. 2853 - 2861
反应条件
Lipozyme lipase enzyme in phosphate buffer T=20°C; pH=7; 6 h; Product distribution; Further Variations:pH-valuesSolventstime;
参考文献
Tetrahedron Letters, , vol. 43, # 42 p. 7585 - 7587
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 17 p. 2549 - 2554
