1-苄基-5-氧代-3-吡咯烷甲酸合成路线 （共 17 条）
反应条件
1: Red-Al / toluene; tetrahydrofuran / 2.5 h / Heating 2: ammonium formate / Pd/C / methanol / 0.25 h / Heating View Scheme
参考文献
Polla, Magnus O.; Tottie, Louise; Norden, Carita; Linschoten, Marcel; Muesil, Djordje; Trumpp-Kallmeyer, Susanne; Aukrust, Inger R.; Ringom, Rune; Holm, Kjetil H.; Neset, Siren M.; Sandberg, Marcel; Thurmond, John; Yu, Peng; Hategan, Georgeta; Anderson, Herb
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1151 - 1175
反应条件
1: Red-Al / toluene; tetrahydrofuran / 2.5 h / Heating 2: ammonium formate / Pd/C / methanol / 0.25 h / Heating View Scheme
参考文献
Polla, Magnus O.; Tottie, Louise; Norden, Carita; Linschoten, Marcel; Muesil, Djordje; Trumpp-Kallmeyer, Susanne; Aukrust, Inger R.; Ringom, Rune; Holm, Kjetil H.; Neset, Siren M.; Sandberg, Marcel; Thurmond, John; Yu, Peng; Hategan, Georgeta; Anderson, Herb
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1151 - 1175
反应条件
1: Red-Al / toluene; tetrahydrofuran / 2.5 h / Heating 2: ammonium formate / Pd/C / methanol / 0.25 h / Heating View Scheme
参考文献
Polla, Magnus O.; Tottie, Louise; Norden, Carita; Linschoten, Marcel; Muesil, Djordje; Trumpp-Kallmeyer, Susanne; Aukrust, Inger R.; Ringom, Rune; Holm, Kjetil H.; Neset, Siren M.; Sandberg, Marcel; Thurmond, John; Yu, Peng; Hategan, Georgeta; Anderson, Herb
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1151 - 1175
反应条件
1: Red-Al / toluene; tetrahydrofuran / 2.5 h / Heating 2: ammonium formate / Pd/C / methanol / 0.25 h / Heating 3: 3.82 g / K2CO3 / tetrahydrofuran; H2O / 0 - 20 °C View Scheme
参考文献
Polla, Magnus O.; Tottie, Louise; Norden, Carita; Linschoten, Marcel; Muesil, Djordje; Trumpp-Kallmeyer, Susanne; Aukrust, Inger R.; Ringom, Rune; Holm, Kjetil H.; Neset, Siren M.; Sandberg, Marcel; Thurmond, John; Yu, Peng; Hategan, Georgeta; Anderson, Herb
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1151 - 1175
反应条件
1: Red-Al / toluene; tetrahydrofuran / 2.5 h / Heating 2: ammonium formate / Pd/C / methanol / 0.25 h / Heating 3: 3.82 g / K2CO3 / tetrahydrofuran; H2O / 0 - 20 °C 4: 97 percent / Et3N / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Polla, Magnus O.; Tottie, Louise; Norden, Carita; Linschoten, Marcel; Muesil, Djordje; Trumpp-Kallmeyer, Susanne; Aukrust, Inger R.; Ringom, Rune; Holm, Kjetil H.; Neset, Siren M.; Sandberg, Marcel; Thurmond, John; Yu, Peng; Hategan, Georgeta; Anderson, Herb
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1151 - 1175
反应条件
thionyl chloride in 1,4-dioxane
T=90 - 100°C; 0.5 h;
参考文献
Imamura, Shinichi; Ishihara, Yuji; Hattori, Taeko; Kurasawa, Osamu; Matsushita, Yoshihiro; Sugihara, Yoshihiro; Kanzaki, Naoyuki; Iizawa, Yuji; Baba, Masanori; Hashiguchi, Shohei
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 1 p. 63 - 73
反应条件
racemate separation via diastereomeric salt formation;
参考文献
Morimoto, Masao; Yamakawa, Atsushi; Katagiri, Hiroshi; Sakai, Kenichi
Tetrahedron Asymmetry, 2007 , vol. 18, # 24 p. 2869 - 2875
