1-苄基-5-氧代-3-吡咯烷甲酸合成路线 （共 17 条）
反应条件
lithium hydroxide in tetrahydrofuran; methanol; water 0.333333 h; Heating / reflux;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 78 ;
EP 1403255 A1
反应条件
T=130°C; Inert atmosphere;
参考文献
Gallagher, Timothy; Derrick, Ian; Durkin, Patrick M.; Haseler, Claire A.; Hirschhaeuser, Christoph; Magrone, Pietro
Journal of Organic Chemistry, 2010 , vol. 75, # 11 p. 3766 - 3774
反应条件
in 1,4-dioxane; methanol; aqueous KOH
反应条件
1: 99 percent / methanol / Heating 2: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
1: 99 percent / methanol / Heating 2: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
sulfuric acid 3 h; Heating;
参考文献
Stanetty, Peter; Turner, Martin; Mihovilovic, Marko D.
Molecules, 2005 , vol. 10, # 2 p. 367 - 375
反应条件
1: 5-oxo-1-(phenylmethyl)-3-pyrrolidinecarboxylic acid With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: 1-((E)-2-Nitro-2-phenyl-vinyl)-pyrrolidine in tetrahydrofuran T=-78 - 64°C; 3: methanol With chloro-trimethyl-silane
参考文献
Felluga, Fulvia; Gombac, Valentina; Pitacco, Giuliana; Valentin, Ennio; Zangrando, Ennio; Morganti, Stefano; Rizzato, Egon; Spinelli, Domenico; Petrillo, Giovanni
Tetrahedron, 2006 , vol. 62, # 37 p. 8787 - 8791
反应条件
1: 5-oxo-1-(phenylmethyl)-3-pyrrolidinecarboxylic acid With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: (E)-1-(1-pyrrolidinyl)-2-nitro-2-[2-(methylthio)phenyl]ethene in tetrahydrofuran T=-78 - 64°C; 3: methanol With chloro-trimethyl-silane
参考文献
Felluga, Fulvia; Gombac, Valentina; Pitacco, Giuliana; Valentin, Ennio; Zangrando, Ennio; Morganti, Stefano; Rizzato, Egon; Spinelli, Domenico; Petrillo, Giovanni
Tetrahedron, 2006 , vol. 62, # 37 p. 8787 - 8791
反应条件
1: Red-Al / toluene; tetrahydrofuran / 2.5 h / Heating 2: ammonium formate / Pd/C / methanol / 0.25 h / Heating 3: 3.82 g / K2CO3 / tetrahydrofuran; H2O / 0 - 20 °C 4: 97 percent / Et3N / CH2Cl2 / 0 - 20 °C 5: 78 percent / LiBr / acetone / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1151 - 1175
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in tetrahydrofuran; toluene 2.5 h; Heating;
参考文献
Polla, Magnus O.; Tottie, Louise; Norden, Carita; Linschoten, Marcel; Muesil, Djordje; Trumpp-Kallmeyer, Susanne; Aukrust, Inger R.; Ringom, Rune; Holm, Kjetil H.; Neset, Siren M.; Sandberg, Marcel; Thurmond, John; Yu, Peng; Hategan, Georgeta; Anderson, Herb
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1151 - 1175
