4-甲基-3-甲基硫代-5-(4-吡啶)-1,2,4-噻唑合成路线 (共 3 条)
反应条件
potassium permanganate; water; acetic acid T=20°C; 3 h;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2005/80379 A1, 2005 ;
Location in patent: Page/Page column 40-41 ;
WO 2005/080379 A1
反应条件
m-chloro-peroxy-benzoic acid; 3-chloro-benzenecarboperoxoic acid
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US4900743 A1, 1990 ;
反应条件
sodium hydroxide in ethanol
T=20°C;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2005/80379 A1, 2005 ;
Location in patent: Page/Page column 40 ;
WO 2005/080379 A1