N-BOC-GAMMA-氨基丁酸合成路线 （共 39 条）
反应条件
1: [14C]-4-Aminobutyric acid With triethylamine in 1,4-dioxane; water T=10°C; 0.333333 h; 2: di-tert-butyl dicarbonate in 1,4-dioxane; water T=15 - 17°C; 12 h; 3: With hydrogenchloride in 1,4-dioxane; water
参考文献
RAMOT AT TEL AVIV UNIVERSITY LTD.; BAR-ILAN UNIVERSITY; BIOLINERX LTD.
Patent: WO2008/10222 A2, 2008 ;
Location in patent: Page/Page column 36-37 ;
WO 2008/010222 A2
反应条件
sodium hydroxide in tetrahydrofuran T=20°C; 3 h;
参考文献
Sinha, Manish; Dola, Vasanth R.; Agarwal, Pooja; Srivastava, Kumkum; Haq, Wahajul; Puri, Sunil K.; Katti, Seturam B.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 14 p. 3573 - 3586
反应条件
1: 4-aminobutyric acid ethyl ester hydrochloride With water; sodium hydroxide T=80°C; 4 h; 2: di-tert-butyl dicarbonate in 1,4-dioxane T=20°C; 4 h; 3: With hydrogenchloride in water pH=3;
参考文献
Conrig Pharma ApS; Hansen, John Bondo; Thomsen, Mikael Søndergaard
Patent: US2013/303497 A1, 2013 ;
Location in patent: Paragraph 0249-0252 ;
反应条件
triethylamine in 1,4-dioxane; water 2 h; Ambient temperature;
参考文献
Boswell, Henry D.; Watson, Allan B.; Walton, Nicholas J.; Robins, David J.
Phytochemistry (Elsevier), 1993 , vol. 34, # 1 p. 153 - 156
反应条件
1: With lithium hydroxide hydrate; water in tetrahydrofuran T=20°C; 4 h; 2: With hydrogenchloride in water pH=3 - 4; Product distribution / selectivity;
参考文献
Conrig Pharma ApS; Hansen, John Bondo; Thomsen, Mikael Søndergaard
Patent: US2013/303497 A1, 2013 ;
Location in patent: Paragraph 0279-0281 ;
反应条件
para-dicyanobenzene; t-DDT; phenanthrene; sodium hydroxide in water; acetonitrile T=20°C; 2 h; Irradiation;
参考文献
Yoshimi, Yasuharu; Itou, Tatsuya; Hatanaka, Minoru
Chemical Communications, 2007 , # 48 p. 5244 - 5246
反应条件
triethylamine in 1,4-dioxane; water
参考文献
Lippard, Stephen J.; Barnes, Carmen M.; Haskel, Ariel; Barnes, Katie R.
Patent: US2004/235712 A1, 2004 ;
Location in patent: Page column 34 ;
反应条件
sodium hydroxide in 1,4-dioxane; water 2 h;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Ragozhin, S. V.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 10 p. 2385 - 2389,2132 - 2134
反应条件
lithium hydroxide in tetrahydrofuran T=25°C; 0.333333 h;
参考文献
Flynn, Daniel L.; Zelle, Robert E.; Grieco, Paul A.
Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2424 - 2426
反应条件
phosphate buffer; Bacillus subtilis esterase in methanol; hexane T=37°C; 24 h;
参考文献
Barbayianni, Efrosini; Fotakopoulou, Irene; Schmidt, Marlen; Constantinou-Kokotou, Violetta; Bornscheuer, Uwe T.; Kokotos, George
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8730 - 8733
