反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes
T=-78 - -65°C; 1 h;
2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran; hexanes
T=-78 - -65°C; 1 h;
参考文献
IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y; SPROTT, Kevin
Patent: WO2012/88431 A1, 2012 ;
Location in patent: Page/Page column 107-108 ;
WO 2012/088431 A1
