5-氯甲基-3-(4-氯苯基)-1,2,4-氧二唑合成路线 （共 8 条）
反应条件
triethylamine in benzene 10 h; Reflux;
参考文献
Dueruest, Yaar; Karaku, Hamza; Kaiser, Marcel; Tasdemir, Deniz
European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 296 - 304
反应条件
in toluene 2 h; RefluxMolecular sieve;
参考文献
Ozcan, Sevil; Kazi, Aslamuzzaman; Marsilio, Frank; Fang, Bin; Guida, Wayne C.; Koomen, John; Lawrence, Harshani R.; Sebti, Said M.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 3783 - 3805
反应条件
1: NH2OH*HCl; Et3N / ethanol / Heating 2: DIEA / 1,2-dichloro-ethane / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 2 p. 302 - 306
反应条件
1: DIEA / CH2Cl2 / 24 h / 20 °C 2: toluene / 24 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 3 p. 609 - 612
反应条件
1.1: 8-hydroxyquinoline; hydroxylamine hydrochloride; sodium carbonate / H2O; ethanol / Heating 2.1: potassium carbonate / CH2Cl2 / 3 h 2.2: toluene / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 11 p. 2815 - 2824
反应条件
N-ethyl-N,N-diisopropylamine in 1,2-dichloro-ethane Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 2 p. 302 - 306
反应条件
1: With potassium carbonate in dichloromethane 3 h; 2: in toluene 5 h; Heating; Title compound not separated from byproducts;
参考文献
Cottrell, Denise M.; Capers, Jeffrey; Salem, Manar M.; DeLuca-Fradley, Kate; Croft, Simon L.; Werbovetz, Karl A.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2815 - 2824
反应条件
sodium acetate; acetic acid Heating;
参考文献
Palazzo,G.; Silvestrini,B.
Bollettino Chimico Farmaceutico, 1962 , vol. 101, p. 251 - 258
