1: n-BuLi / 17 h / 0 - 20 °C 2: 4 N aq. HCl / methanol; dioxane / 50 °C View Scheme

1: n-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C 2: 4 N aq. HCl / methanol; dioxane / 50 °C 3: K2CO3 / acetone / 15 h / 60 °C 4: NaOEt / ethanol / 20 h / 0 °C 5: K2CO3 / dimethylformamide / 20 °C View Scheme

1: n-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C 2: 4 N aq. HCl / methanol; dioxane / 50 °C View Scheme

1: iodine; silver(I) acetate / chloroform / 5 h / 20 °C / Inert atmosphere 2: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 1 h / -100 - -78 °C / Inert atmosphere; Cooling with liquid nitrogen/methanol 3: ammonium chloride / tetrahydrofuran; diethyl ether; hexane / 1 h / 20 °C / Inert atmosphere; Saturated solution 4: palladium 10 on activated carbon; sodium carbonate / ethylene glycol dimethyl ether; water / 40 - 45 °C / Inert atmosphere 5: hydrogenchloride; water / methanol / 12 h / 50 °C View Scheme

1: n-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C 2: 4 N aq. HCl / methanol; dioxane / 50 °C View Scheme

1.1: n-BuLi / tetrahydrofuran / 1.5 h / 0 °C 1.2: 78 percent / tetrahydrofuran / 1 h / 0 °C 2.1: 2.97 g / aq. HCl / tetrahydrofuran; methanol / 36 h / Heating View Scheme

1: n-BuLi / 17 h / 0 - 20 °C 2: 4 N aq. HCl / methanol; dioxane / 50 °C 3: K2CO3 / acetone / 15 h / 60 °C 4: NaOEt / ethanol / 20 h / 0 °C View Scheme

1: n-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C 2: 4 N aq. HCl / methanol; dioxane / 50 °C 3: K2CO3 / acetone / 15 h / 60 °C 4: NaOEt / ethanol / 20 h / 0 °C 5: K2CO3 / dimethylformamide / 20 °C View Scheme

1: n-BuLi / tetrahydrofuran / 1 h / -78 - 20 °C 2: 4 N aq. HCl / methanol; dioxane / 50 °C 3: K2CO3 / acetone / 15 h / 60 °C 4: NaOEt / ethanol / 20 h / 0 °C 5: K2CO3 / dimethylformamide / 20 °C View Scheme

1: 1.) n-BuLi/hexane / 1.) THF, r.t, 20 min; 2.) THF, -72 deg C, 2 h -> -20 deg C, 40 min 2: 1.) 70percent sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran / 1.) 0 deg C, 1 h; 2.) r.t., 0.5 h View Scheme