2-甲基-3,4-二甲氧基苯甲酸合成路线 （共 24 条）
反应条件
1: 6-bromo-2,3-dimethoxy toluene With methyl-magnesium chloride; magnesium in tetrahydrofuran T=25°C; Inert atmosphereLarge scale; 2: carbon dioxide in tetrahydrofuran; water T=-60°C; Inert atmosphereLarge scale; 3: With sulfuric acid in tetrahydrofuran; water T=25 - 30°C; 1 h; Inert atmosphereLarge scale;
参考文献
Connolly, Terrence J.; Matchett, Michael; McGarry, Patrick; Sukhtankar, Sunil; Zhu, Jiang
Organic Process Research and Development, 2004 , vol. 8, # 4 p. 624 - 627
反应条件
1: lithium 3,4-dimethoxybenzoate With 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran T=0°C; 2 h; 2: methyl iodide in tetrahydrofuran T=0 - 66°C; 3 h; 3: With hydrogenchloride; water in diethyl ether pH=1 - 2;
参考文献
US2010/331398 A1, ;
Page/Page column 14 ;
反应条件
sodium hypochlorite T=60 - 70°C; 0.666667 h;
参考文献
Borchardt, Ronald T.; Bhatia, Pramila
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 263 - 271
反应条件
1: 3,4-dimethoxy-benzoic acid With n-butyllithium; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane T=-78 - 0°C; 2: methyl iodide in tetrahydrofuran; hexane T=0 - 40°C; 3 h; Further stages.;
参考文献
Tetrahedron, , vol. 64, # 46 p. 10552 - 10557
反应条件
1: 3,4-dimethoxy-benzoic acid With lithium diisopropyl amide in tetrahydrofuran T=66°C; 2 h; 2: methyl iodide in tetrahydrofuran T=40°C; Further stages.;
参考文献
Chau, Nguyet Trang Thanh; Nguyen, Thi Huu; Castanet, Anne-Sophie; Nguyen, Kim Phi Phung; Mortier, Jacques
Tetrahedron, 2008 , vol. 64, # 46 p. 10552 - 10557
反应条件
1: 83 percent / K2CO3 / acetone / 3 h / Heating 2: 70 percent / polyphosphoric acid / 1.5 h / 45 - 50 °C 3: 81.5 percent / aq. NaOCl / 0.67 h / 60 - 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 3 p. 263 - 271
反应条件
potassium permanganate in acetone
参考文献
Journal of Organic Chemistry, , vol. 33, # 2 p. 494 - 503
反应条件
1: aluminium chloride; carbon disulfide / 40 - 50 °C 2: sodium hypoiodite View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , p. 573,587
反应条件
1: 3,4-dimethoxy-benzoic acid With n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane T=-78 - -50°C; 2 h; 2: methyl iodide in tetrahydrofuran; hexane T=-78 - 20°C; Further stages.;
参考文献
Tetrahedron, , vol. 64, # 46 p. 10552 - 10557
反应条件
1: sec.-butyllithium; 3,4-dimethoxy-benzoic acid With N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane; cyclohexane T=-78 - -30°C; 2 h; 2: methyl iodide in tetrahydrofuran; hexane; cyclohexane T=-30 - 20°C; Further stages.;
参考文献
Tetrahedron, , vol. 64, # 46 p. 10552 - 10557
