2-羟基-4,5-二甲氧基苯甲酸合成路线 （共 26 条）
参考文献
Clark
Journal of the American Chemical Society, 1931 , vol. 53, p. 3431,3433
反应条件
sulfuric acid in methanol; argon; toluene
参考文献
ZERIA PHARMACEUTICAL CO., LTD.
Patent: EP1792888 A1, 2007 ;
反应条件
sulfuric acid in toluene 2.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
Zeria Pharmaceutical Co., LTD; Nakao, Ryu
Patent: US2013/253222 A1, 2013 ;
Location in patent: Paragraph 0039 ;
反应条件
thionyl chloride in methanol; anhydrous xylene
参考文献
ZERIA PHARMACEUTICAL CO., LTD.
Patent: WO2006/22252 A1, 2006 ;
Location in patent: Page/Page column 10 ;
参考文献
Clark
Journal of the American Chemical Society, 1931 , vol. 53, p. 3431,3433
反应条件
hydrogenchloride; AlCl3 in water; argon; N,N-dimethyl-formamide; toluene
参考文献
ZERIA PHARMACEUTICAL CO., LTD.
Patent: WO2006/22252 A1, 2006 ;
Location in patent: Page/Page column 9-10 ;
反应条件
hydrogenchloride; sodium hydroxide; sodium bromide in water; argon; ethyl acetate
参考文献
ZERIA PHARMACEUTICAL CO., LTD.
Patent: EP1792888 A1, 2007 ;
反应条件
potassium hydroxide in 1,4-dioxane
参考文献
Omura; Nakagawa; Kushida; Lukacs
Journal of the American Chemical Society, 1986 , vol. 108, # 19 p. 6088 - 6089
反应条件
potassium hydroxide in 1,4-dioxane
参考文献
Omura; Nakagawa; Kushida; Lukacs
Journal of the American Chemical Society, 1986 , vol. 108, # 19 p. 6088 - 6089
参考文献
Arnold; Bordwell
Journal of the American Chemical Society, 1942 , vol. 64, p. 2983,2985
