吡啶并[3,2-D][1,3]噻唑-2-硫醇合成路线 (共 10 条)
反应条件
in N,N-dimethyl-formamide T=130°C;
参考文献
AMGEN INC.; Allen, Jennifer R.; Amegadzie, Albert; Andrews, Kristin L.; Brown, James; Chen, Jian J.; Chen, Ning; Harrington, Essa Hu; Liu, Qingyian; Nguyen, Thomas T.; Pickrell, Alexander J.; Qian, Wenyuan; Rumfelt, Shannon; Rzasa, Robert M.; Yuan, Chester Chenguang; Zhong, Wenge
Patent: US2013/225552 A1, 2013 ;
Location in patent: Paragraph 0654 ;
反应条件
pyridine 24 h; Heating;
参考文献
Barlin; Ireland; Rowland
Australian Journal of Chemistry, 1984 , vol. 37, # 8 p. 1729 - 1737
参考文献
Yakugaku Zasshi, , vol. 71, p. 916,919
Chem.Abstr., , p. 8109
反应条件
sodium in ethylene glycol dimethyl ether; ethanol
0.166667 h; Heating;
参考文献
Walczyski, Krzysztof; Zuiderveld, Obbe P.; Timmerman, Henk
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 1 p. 15 - 23
反应条件
1: NaH
2: aq. KMnO4
View Scheme
参考文献
Gayral; Bourdais; Lorre; et al.
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 2 p. 171 - 175
参考文献
Gayral; Bourdais; Lorre; et al.
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 2 p. 171 - 175
反应条件
sodium in ethylene glycol dimethyl ether; ethanol
0.166667 h; Heating;
参考文献
Walczyski, Krzysztof; Zuiderveld, Obbe P.; Timmerman, Henk
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 1 p. 15 - 23
反应条件
potassium carbonate in tetrahydrofuran
T=20°C; 19 h;
参考文献
AMGEN INC.; Allen, Jennifer R.; Amegadzie, Albert; Andrews, Kristin L.; Brown, James; Chen, Jian J.; Chen, Ning; Harrington, Essa Hu; Liu, Qingyian; Nguyen, Thomas T.; Pickrell, Alexander J.; Qian, Wenyuan; Rumfelt, Shannon; Rzasa, Robert M.; Yuan, Chester Chenguang; Zhong, Wenge
Patent: US2013/225552 A1, 2013 ;
Location in patent: Paragraph 0655; 0656 ;
反应条件
1: aq. NaOH / ethanol / Heating
2: N2H4*H2O / propan-2-ol / Heating
View Scheme
参考文献
Bednyagina,N.P. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1975 , vol. 11, p. 811 - 813
Khimiya Geterotsiklicheskikh Soedinenii, 1975 , vol. 11, # 7 p. 925 - 927
反应条件
sodium in ethylene glycol dimethyl ether; ethanol
0.166667 h; Heating;
参考文献
Walczyski, Krzysztof; Zuiderveld, Obbe P.; Timmerman, Henk
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 1 p. 15 - 23