2-氯-1-[1-(4-氯苯基)-2,5-二甲基-1H-吡咯-3-基]-1-乙酮合成路线 （共 3 条）
反应条件
1: chloroacetyl chloride With AlCl3, aluminium chloride in 1,2-dichloro-ethane
T=0°C; 0.5 h;
2: 1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrole in 1,2-dichloro-ethane
T=0 - 20°C; 2 h;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; FINLEY, Daniel; KING, Randall, W.; LEE, Byung-Hoon; LEE, Min, Jae; GAHMAN, Timothy, C.
Patent: WO2011/94545 A2, 2011 ;
Location in patent: Page/Page column 71 ;
WO 2011/094545 A1
反应条件
1.1: acetic acid / 1 h / 100 °C
2.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 0.5 h / 0 °C
2.2: 2 h / 0 - 20 °C
View Scheme
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; FINLEY, Daniel; KING, Randall, W.; LEE, Byung-Hoon; LEE, Min, Jae; GAHMAN, Timothy, C.
Patent: WO2011/94545 A2, 2011 ;
WO 2011/094545 A1
反应条件
1.1: acetic acid / 1 h / 100 °C
2.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 0.5 h / 0 °C
2.2: 2 h / 0 - 20 °C
View Scheme
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; FINLEY, Daniel; KING, Randall, W.; LEE, Byung-Hoon; LEE, Min, Jae; GAHMAN, Timothy, C.
Patent: WO2011/94545 A2, 2011 ;
WO 2011/094545 A1
