1,2,3,4-四氢异喹啉-3-羧酸甲酯合成路线 （共 12 条）
参考文献
Ilyn, Alexey P.; Trifilenkov, Andrey S.; Kovrigin, Denis I.; Yudin, Michail V.; Ivachtchenko, Alexandre V.
Heterocyclic Communications, 2006 , vol. 12, # 2 p. 107 - 110
参考文献
US5518735 A1, ;
US 5518735 A
反应条件
1: aq. HCl / a) 100 deg C, 3.5 h, b) RT, overnight 2: 1.) thionyl chloride, 2.) triethylamine / 1.) reflux, overnight, 2.) water, RT, 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 9 p. 1267 - 1277
反应条件
1: 82 percent / NH3 / methanol / 336 h / 20 °C 2: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Hetenyi, Anasztazia; Martinek, Tamas A.; Lazar, Laszlo; Zalan, Zita; Fueloep, Ferenc
Journal of Organic Chemistry, 2003 , vol. 68, # 14 p. 5705 - 5712
反应条件
chicken liver acetone; water pH=7.5; 2 h;
参考文献
Sanchez, Remedios; Luna, Hector; Perez, Herminia I.; Manjarrez, Norberto; Solis, Aida
Tetrahedron Asymmetry, 2001 , vol. 12, # 10 p. 1399 - 1401
反应条件
ammonia in methanol T=20°C; 336 h;
参考文献
Hetenyi, Anasztazia; Martinek, Tamas A.; Lazar, Laszlo; Zalan, Zita; Fueloep, Ferenc
Journal of Organic Chemistry, 2003 , vol. 68, # 14 p. 5705 - 5712
反应条件
1: Pd/C / xylene / Heating 2: 98 percent / methanolic NH3 / Ambient temperature 3: 92 percent / triethylamine, trifluoroacetic anhydride / CH2Cl2 / 0.03 h / 0 °C View Scheme
参考文献
Langry, Kevin C.
Organic Preparations and Procedures International, 1994 , vol. 26, # 4 p. 429 - 438
反应条件
diphenylselenium bis(trifluoroacetate) in ethylene glycol dimethyl ether Ambient temperature;
参考文献
Marino, J.P.; Larsen, Robert D.
Journal of the American Chemical Society, 1981 , vol. 103, # 15 p. 4642 - 4643
反应条件
palladium in toluene T=110°C; 15 h; regiospecific reaction;
参考文献
Grigg, Ronald; Somasunderam, Anoma; Sridharan, Visuvanathar; Keep, Ann
Synlett, 2009 , # 1 p. 97 - 99
反应条件
1: With N-chloro-succinimide in diethyl ether T=0 - 20°C; Chlorination; 1 h; 2: With triethylamine in diethyl ether T=0 - 20°C; Dehydrochlorination; 2 h; Further stages.;
参考文献
Czombos, Jozsef; Aelterman, Wim; Tkachev, Alexey; Martins, Jose C.; Tourwe, Dirk; Peter, Antal; Toeth, Geza; Fueloep, Ferenc; De Kimpe, Norbert
Journal of Organic Chemistry, 2000 , vol. 65, # 18 p. 5469 - 5475
