1,3-二氮杂烷-2-硫酮合成路线 （共 8 条）
反应条件
in ethanol 0.0833333 h; Heating;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 20, # 6 p. 672 - 675
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 20, # 6 p. 823 - 826
反应条件
in acetone 0.25 h; Heating / reflux;
参考文献
ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.
Patent: WO2005/80397 A2, 2005 ;
Location in patent: Page/Page column 44 ;
WO 2005/080397 A2
反应条件
potassium carbonate in acetonitrile 4 h; Heating;
参考文献
Bogat-skii, A. V.; Luk'yanenko, N. G.; Kirichenko, T. I.; Limich, V. V.; Nazarova, N. Yu.; Karpenko, L. P.
Journal of Organic Chemistry USSR (English Translation), 1985 , p. 1379 - 1385
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 7 p. 1513 - 1519
反应条件
1: K2CO3 / 18-crown-6 / acetonitrile / 4 h 2: 200 °C / 1 Torr View Scheme
参考文献
Bogatsky, A. V.; Lukyanenko, N. G.; Kirichenko, T. I.; Limich, V. V.
Synthesis, 1984 , # 2 p. 136
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
5 h; Heating;
参考文献
Bogatsky, A. V.; Lukyanenko, N. G.; Kirichenko, T. I.
Synthesis, 1982 , # 6 p. 464 - 465
反应条件
1: 60 percent / 30percent H2O2, 10percent aq. NaOH / 0.5 h / 70 °C
2: 1.) NaH / 1.) dioxane, from 55 deg C to 60 deg C, 4 h, 2.) dioxane, reflux, 3.5 h
View Scheme
参考文献
Li, Chau-der; Mella, Sharon L.; Sartorelli, Alan C.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 9 p. 1089 - 1092
反应条件
1: 73 percent / K2CO3/18-crown-6 / acetonitrile / 4 h / Heating
View Scheme
参考文献
Bogatsky, A. V.; Lukyanenko, N. G.; Kirichenko, T. I.; Limich, V. V.
Synthesis, 1984 , # 2 p. 136
反应条件
1.1: ethanol / 1 h / Heating
2.1: KOH / ethanol / Heating
3.1: PBr3 / CHCl3 / Heating
3.2: KOH / methanol / 2 h / Heating
View Scheme
参考文献
Cotton, F. Albert; Murillo, Carlos A.; Wang, Xiaoping; Wilkinson, Chad C.
Dalton Transactions, 2006 , # 38 p. 4623 - 4631
