1-甲基-4,5,6,7-四氢-1H-吡咯并[3,2-c]吡啶合成路线 （共 4 条）
反应条件
sodium tetrahydroborate in methanol; water
1 h;
参考文献
Khorana, Nantaka; Smith, Carol; Herrick-Davis, Kathy; Purohit, Anil; Teitler, Milt; Grella, Brian; Dukat, Malgorzata; Glennon, Richard A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3930 - 3937
反应条件
1: 60 percent / 7 h / Heating
2: 36 percent / POCl3 / toluene / 3 h / Heating
3: 0.23 g / NaBH4 / H2O; methanol / 1 h
View Scheme
参考文献
Khorana, Nantaka; Smith, Carol; Herrick-Davis, Kathy; Purohit, Anil; Teitler, Milt; Grella, Brian; Dukat, Malgorzata; Glennon, Richard A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3930 - 3937
反应条件
1: 69 percent / LiAlH4 / tetrahydrofuran / 5 h / 20 °C
2: 60 percent / 7 h / Heating
3: 36 percent / POCl3 / toluene / 3 h / Heating
4: 0.23 g / NaBH4 / H2O; methanol / 1 h
View Scheme
参考文献
Khorana, Nantaka; Smith, Carol; Herrick-Davis, Kathy; Purohit, Anil; Teitler, Milt; Grella, Brian; Dukat, Malgorzata; Glennon, Richard A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3930 - 3937
反应条件
1: 36 percent / POCl3 / toluene / 3 h / Heating
2: 0.23 g / NaBH4 / H2O; methanol / 1 h
View Scheme
参考文献
Khorana, Nantaka; Smith, Carol; Herrick-Davis, Kathy; Purohit, Anil; Teitler, Milt; Grella, Brian; Dukat, Malgorzata; Glennon, Richard A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3930 - 3937
