N-(4-甲氧基苄基)-1-金刚烷胺合成路线 （共 6 条）
反应条件
sodium cyanoborohydride in methanol
T=20°C; 20 h;
参考文献
Barniol-Xicota, Marta; Turcu, Andreea L.; Codony, Sandra; Escolano, Carmen; Vazquez, Santiago
Tetrahedron Letters, 2014 , vol. 55, # 15 p. 2548 - 2550
反应条件
sodium cyanoborohydride in methanol
T=20°C; Inert atmosphere;
参考文献
Wang, Jizhou; Ma, Chunlong; Wang, Jun; Jo, Hyunil; Canturk, Belgin; Fiorin, Giacomo; Pinto, Lawrence H.; Lamb, Robert A.; Klein, Michael L.; DeGrado, William F.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2804 - 2812
反应条件
chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium(II); caesium carbonate in tetrahydrofuran; water
T=60°C; Suzuki-Miyaura cross-coupling reaction; 24 h; Inert atmosphere;
参考文献
Fleury-Bregeot, Nicolas; Raushel, Jessica; Sandrock, Deidre L.; Dreher, Spencer D.; Molander, Gary A.
Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9564 - 9570
反应条件
1: tetrahydrofuran; tert-butyl alcohol / 80 °C
2: chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium(II); caesium carbonate / tetrahydrofuran; water / 24 h / 60 °C / Inert atmosphere
View Scheme
参考文献
Fleury-Bregeot, Nicolas; Raushel, Jessica; Sandrock, Deidre L.; Dreher, Spencer D.; Molander, Gary A.
Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9564 - 9570
反应条件
1: sodium hydrogensulfite / ethanol / 16 h / 30 - 35 °C
2: sodium cyanoborohydride / methanol / 20 h / 20 °C
View Scheme
参考文献
Barniol-Xicota, Marta; Turcu, Andreea L.; Codony, Sandra; Escolano, Carmen; Vazquez, Santiago
Tetrahedron Letters, 2014 , vol. 55, # 15 p. 2548 - 2550
反应条件
C39H47Cl3FeN2O
T=23°C; 12 h; chemoselective reaction;
参考文献
Hennessy, Elisabeth T.; Liu, Richard Y.; Iovan, Diana A.; Duncan, Ryan A.; Betley, Theodore A.
Chemical Science, 2014 , vol. 5, # 4 p. 1526 - 1532
