1,1,3,4-四甲基-2-茚酮合成路线 （共 47 条）
反应条件
1: 78 percent / hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 96 h / Heating
2: 80 percent / selenium(I) bromide, Et3N / CH2Cl2 / 0.5 h / Ambient temperature
3: 50 percent / benzene / 14 h / Heating
View Scheme
参考文献
Guziec, Frank S.; Sanfilippo, Lynn James; Murphy, Christopher J.; Moustakis, Christine A.; Cullen, Edward R.
Tetrahedron, 1985 , vol. 41, # 21 p. 4843 - 4852
反应条件
titanium tetrachloride
T=185°C; 4 h;
参考文献
Knorr, Rudolf; Ferchland, Kathrin; Mehlstaeubl, Johann; Boehrer, Petra; Hoang, Thi Phung; Stephenson, David S.
Chemische Berichte, 1992 , vol. 125, # 19 p. 2031 - 2040
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-50 - -20°C; 2.25 h;
参考文献
Knorr, Rudolf; Pires, Claudio; Behringer, Claudia; Menke, Thomas; Freudenreich, Johannes; Rossmann, Eva C.; Boehrer, Petra
Journal of the American Chemical Society, 2006 , vol. 128, # 46 p. 14845 - 14853
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -55 deg C, room temp., 90 min; 2.) THF, -65 deg C, room temp.
2: CH2Cl2 / 0.17 h
3: benzyltriethylammonium chloride, NaOH / CH2Cl2
4: MgBr2 / diethyl ether / 1 h
View Scheme
参考文献
Knorr, Rudolf; Freudenreich, Johannes; Von Roman, Therese; Mehlstaeubl, Johann; Boehrer, Petra
Tetrahedron, 1993 , vol. 49, # 39 p. 8837 - 8854
反应条件
in benzene
Irradiation;
参考文献
Ng, Danny; Yang, Zhe; Garcia-Garibay, Miguel A.
Tetrahedron Letters, 2002 , vol. 43, # 39 p. 7063 - 7066
反应条件
in acetonitrile-D3
T=-40°C; 1 h; Irradiation; Title compound not separated from byproducts;
参考文献
Korth; Sustmann; Lommes; Paul; Ernst; De Groot; Hughes; Ingold
Journal of the American Chemical Society, 1994 , vol. 116, # 7 p. 2767 - 2777
反应条件
nitrogen(II) oxide; nitrogen(IV) oxide in acetonitrile
multistep reaction, also with Kupffer cells;
参考文献
Korth, Hans-Gert; Ingold, Keith U.; Sustmann, Reiner; Groot, Herbert de; Sies, Helmut
Angewandte Chemie, 1992 , vol. 104, # 7 p. 915 - 917
