1: benzene / 72 h / 40 - 50 °C 2: 0.1N HCl 3: imidazole / CH2Cl2 / Heating 4: 52 percent View Scheme

1: 1.) Mg / 1.) THF, 2.) reflux, 2 h 2: 62 percent / NaHCO3 / tetrahydrofuran; H2O / 24 h / Heating 3: 2 N aq. HCl / acetone; H2O / 24 h / 40 °C 4: 57 percent / benzene / 50 h / 30 - 40 °C 5: 82 percent / 2 N aq. Na2CO3 / dioxane / 5 h / Heating View Scheme

1: 1.) Mg / 1.) THF, 2.) reflux, 2 h 2: 62 percent / NaHCO3 / tetrahydrofuran; H2O / 24 h / Heating 3: 2 N aq. HCl / acetone; H2O / 24 h / 40 °C View Scheme

1: 1.) Mg / 1.) THF, 2.) reflux, 2 h 2: 62 percent / NaHCO3 / tetrahydrofuran; H2O / 24 h / Heating 3: 2 N aq. HCl / acetone; H2O / 24 h / 40 °C 4: 57 percent / benzene / 50 h / 30 - 40 °C View Scheme