2-氟-5-氨基苯甲酸甲酯合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in methanol P=1034.3 - 1551.4 Torr;
参考文献
Soundararajan, N.; Platz, Matthew S.
Journal of Organic Chemistry, 1990 , vol. 55, # 7 p. 2034 - 2044
反应条件
1: With methanol in hexane; dichloromethane T=0 - 20°C; 0.333333 h; 2: With acetic acid in methanol; hexane; dichloromethane
参考文献
EVOTEC AG
Patent: WO2008/122787 A1, 2008 ;
Location in patent: Page/Page column 91 ;
反应条件
thionyl chloride T=0°C; 12 h; Reflux;
参考文献
Chen, Li; Feng, Lichun; Huang, Mengwei; Liu, Yongfu; Wu, Guolong; Wu, Jim Zhen; Zhou, Mingwei
Patent: US2011/257151 A1, 2011 ;
Location in patent: Page/Page column 79 ;
反应条件
hydrogenchloride in methanol
反应条件
2: 97 percent / H2 / 10percent Pd/C / methanol / 1034.3 - 1551.4 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 7 p. 2034 - 2044
反应条件
1: 94 percent / hydrogen / 5percent Pd-C / acetic acid / 40 - 50 °C 2: 97 percent / thionyl chloride / 1.) 0 deg C, 0.5 h, 2.) room temp., overnight View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 10 p. 3530 - 3543
反应条件
in tetrahydrofuran; hexane T=20 - 21°C; 2 h; Irradiation; Mechanism;
参考文献
Journal of Organic Chemistry, , vol. 55, # 7 p. 2034 - 2044
反应条件
in methanol T=15°C; 4 h; Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 55, # 7 p. 2034 - 2044
反应条件
T=-196°C; 10 h; Irradiation; Mechanism;
参考文献
Journal of Organic Chemistry, , vol. 55, # 7 p. 2034 - 2044
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 5°C; 1.5 h;
参考文献
Tani; Mushika; Yamaguchi
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3530 - 3543
