4,4-二苯基丁烷-1-醇合成路线 （共 21 条）
反应条件
phosphorus tribromide in benzene 1 h; Ambient temperature;
参考文献
Kansal, V. K.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 10 p. 885 - 890
反应条件
triphenylphosphine in dimethyl sulfoxide
参考文献
Warner-Lambert Company
Patent: US5767129 A1, 1998 ;
US 5767129 A
反应条件
carbon palladium in methanol; sulfuric acid
参考文献
AJINOMOTO CO. INC
Patent: US2002/147222 A1, 2002 ;
反应条件
sodium hydrogencarbonate; sodium iodide in dimethyl sulfoxide
T=110°C; 2 h;
参考文献
N'Goka; Schlewer; Linget; Chambon; Wermuth
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2547 - 2557
反应条件
hydrogen; palladium on activated charcoal in ethanol
Hydrogenolysis; P=2585.74 Torr;
参考文献
Ng, Howard P.; Karen, May; Bauman, John G.; Ghannam, Ameen; Islam, Imadul; Liang, Meina; Horuk, Richard; Hesselgesser, Joseph; Snider, R. Michael; Perez, H. Daniel; Morrissey, Michael M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 22 p. 4680 - 4694
反应条件
lithium aluminium tetrahydride in diethyl ether
3 h; Heating;
参考文献
Kansal, V. K.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 10 p. 885 - 890
反应条件
1.1: t-BuOK / tetrahydrofuran / 3 h / 70 °C
1.2: 2.17 g / tetrahydrofuran / 6 h / 70 °C
2.1: 1.31 g / H2 / 10 percent Pd/C / ethanol / 2585.74 Torr
View Scheme
参考文献
Ng, Howard P.; Karen, May; Bauman, John G.; Ghannam, Ameen; Islam, Imadul; Liang, Meina; Horuk, Richard; Hesselgesser, Joseph; Snider, R. Michael; Perez, H. Daniel; Morrissey, Michael M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 22 p. 4680 - 4694
反应条件
1.1: t-BuOK / tetrahydrofuran / 3 h / 70 °C
1.2: 2.17 g / tetrahydrofuran / 6 h / 70 °C
2.1: 1.31 g / H2 / 10 percent Pd/C / ethanol / 2585.74 Torr
View Scheme
参考文献
Ng, Howard P.; Karen, May; Bauman, John G.; Ghannam, Ameen; Islam, Imadul; Liang, Meina; Horuk, Richard; Hesselgesser, Joseph; Snider, R. Michael; Perez, H. Daniel; Morrissey, Michael M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 22 p. 4680 - 4694
反应条件
1: 85 percent / benzoic acid / benzene / 12 h / Heating
2: 100 percent / H2 / 10percent Pd/C / ethanol / 12 h / 2275.5 Torr
3: 90 percent / LiAlH4 / diethyl ether / 5 h / Heating
View Scheme
参考文献
Gualtieri; Teodori; Bellucci; Pesce; Piacenza
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1621 - 1628
反应条件
1: 100 percent / H2 / 10percent Pd/C / ethanol / 12 h / 2275.5 Torr
2: 90 percent / LiAlH4 / diethyl ether / 5 h / Heating
View Scheme
参考文献
Gualtieri; Teodori; Bellucci; Pesce; Piacenza
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1621 - 1628
