1-甲基-2,2-二苯基环丙烷-1-甲腈合成路线 （共 9 条）
反应条件
sodium methylate in methanol
T=55°C; C-anode, Pt-cathode, costant current: 0.5 A, 3.1 F/mol, undivided cell;
参考文献
Chiba, Toshiro; Okimoto, Mitsuhiro; Nagai, Hiroshi; Takata, Yoshiyuki
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 2968 - 2972
反应条件
1: N'-(diphenylmethylene)-4-methylbenzene-1-sulfonohydrazide With sodium hydroxide in 1,4-dioxane
T=80 - 90°C; Bamford-Stevens reaction; 1 h;
2: methyl acrylonitrile T=80 - 90°C; 0.25 h;
参考文献
Jonczyk; Wlostowska; Maakosza
Tetrahedron, 2001 , vol. 57, # 14 p. 2827 - 2832
反应条件
n-butyllithium in diethyl ether
T=-100°C; 1 h;
参考文献
Carlier, Paul R.; Zhang, Yiqun
Organic Letters, 2007 , vol. 9, # 7 p. 1319 - 1322
反应条件
1: p-TsCl; pyridine / 24 h / 80 °C
2: n-BuLi / diethyl ether / 1 h / -100 °C
View Scheme
参考文献
Carlier, Paul R.; Zhang, Yiqun
Organic Letters, 2007 , vol. 9, # 7 p. 1319 - 1322
反应条件
1: 90 percent / (-)-brucine / acetone; methanol / 0.5 h / 60 °C
2: 84 percent / N-hydroxysuccinimide; EDCI / CH2Cl2
3: p-TsCl; pyridine / 24 h / 80 °C
4: n-BuLi / diethyl ether / 1 h / -100 °C
View Scheme
参考文献
Carlier, Paul R.; Zhang, Yiqun
Organic Letters, 2007 , vol. 9, # 7 p. 1319 - 1322
反应条件
1: 84 percent / N-hydroxysuccinimide; EDCI / CH2Cl2
2: p-TsCl; pyridine / 24 h / 80 °C
3: n-BuLi / diethyl ether / 1 h / -100 °C
View Scheme
参考文献
Carlier, Paul R.; Zhang, Yiqun
Organic Letters, 2007 , vol. 9, # 7 p. 1319 - 1322
反应条件
phosphorus pentoxide; triethylamine; benzene
参考文献
Walborsky; Hornyak
Journal of the American Chemical Society, 1955 , vol. 77, p. 6026,6029
反应条件
diethyl ether; lithium diisopropyl amide
anschliessend Erwaermen mit CH3I;
参考文献
Walborsky; Hornyak
Journal of the American Chemical Society, 1955 , vol. 77, p. 6026,6029
反应条件
2: lithium diisopropylamide; diethyl ether / anschliessend Erwaermen mit CH3I
View Scheme
参考文献
Walborsky; Hornyak
Journal of the American Chemical Society, 1955 , vol. 77, p. 6026,6029
