3alpha,21-二羟基-5alpha-孕甾-20-酮合成路线 （共 7 条）
反应条件
potassium carbonate in methanol 0.5 h; Ambient temperature;
参考文献
Purdy, Robert H.; Morrow, Leslie A.; Blinn, James R.; Paul, Steven M.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1572 - 1581
反应条件
perchloric acid in methanol
参考文献
University of Southern California
Patent: US5232917 A1, 1993 ;
US 5232917 A
反应条件
1: 66 percent / BF3*Et2O / benzene / 3 h / 20 °C 2: 88 percent / HCl / H2O; methanol / 18 h View Scheme
参考文献
Steroids, , vol. 66, # 2 p. 99 - 105
反应条件
1: 54 percent / CF3COOH, (C6H5)3P, diethyl azodicarboxylate 2: 35 percent / BF3*Et2O / benzene; methanol / 3 h / 0 °C 3: 96 percent / 10percent aq. K2CO3 / methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1572 - 1581
反应条件
hydrogenchloride in ethanol 24 h; Ambient temperature;
参考文献
Campos Neves, Andre S.; Sa E Melo, Maria Luisa; Moreno, Maria Jose S. M.; Tavares Da Silva, Elisiario J.; Salvador, Jorge A. R.; Da Costa, Saul P.; Martins, Rosa Maria L. M.
Tetrahedron, 1999 , vol. 55, # 11 p. 3255 - 3264
反应条件
1: 60 percent / H2IrCl6*6H2O, H3PO3 / propan-2-ol; H2O 2: Et3N / CH2Cl2 / 1 h / Ambient temperature 3: m-CPBA / hexane / 4 h / 1) -15 deg C, 10 min, 2) room temperature 4: 185 mg / HCl / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 55, # 11 p. 3255 - 3264
反应条件
1: m-CPBA / hexane / 4 h / 1) -15 deg C, 10 min, 2) room temperature 2: 185 mg / HCl / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 55, # 11 p. 3255 - 3264
