Orteronel; 6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-c]咪唑-7-基]-N-甲基-2-萘甲酰胺合成路线 （共 31 条）
反应条件
1.1: 2-(trifluoromethyl)phenyllithium / tetrahydrofuran; hexane / 0.83 h / -65 - -55 °C / Inert atmosphere 1.2: 1.5 h / -65 °C / Inert atmosphere 1.3: Inert atmosphere 2.1: Chiralpak AD column / ethanol; hexane / Resolution of racemate; HPLC conditions View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 21 p. 6356 - 6374
