2,2-二甲基-3-苯丙酸合成路线 （共 33 条）
反应条件
1: 47 percent / N,N-dimethylformamide; oxalyl chloride; hydroxylamine hydrochloride / CH2Cl2 / 4 h / Heating 2: camphorsulfonic acid / CH2Cl2 / 3 h / 20 °C View Scheme
参考文献
Couturier, Michel; Tucker, John L.; Proulx, Caroline; Boucher, Ghislain; Dube, Pascal; Andresen, Brian M.; Ghosh, Arun
Journal of Organic Chemistry, 2002 , vol. 67, # 14 p. 4833 - 4838
反应条件
borane dimethyl sulfide complex in tetrahydrofuran T=0 - 20°C; 13 h; Inert atmosphere;
参考文献
Beaulieu, Louis-Philippe B.; Roman, Daniela Sustac; Vallee, Frederic; Charette, Andre B.
Chemical Communications, 2012 , vol. 48, # 66 p. 8249 - 8251
反应条件
1: With diphenyl phosphoryl azide; triethylamine in toluene 5 h; RefluxCooling; 2: With hydrogenchloride; acetic acid in water T=20°C;
参考文献
GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; BRADY, Gerald, Patrick, Jr.; GALLAGHER, Timothy, Francis; HEERDING, Dirk, A.; MEDINA, Jesus, Raul; ROMERIL, Stuart, Paul
Patent: WO2010/120854 A1, 2010 ;
Location in patent: Page/Page column 115 ;
WO 2010/120854 A1
反应条件
5,10,15,20-tetrakis-pentafluorophenyl-21H,23H-porphyrin iron(III) chloride; iodosylbenzene in dichloromethane 20 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 33, # 34 p. 4949 - 4952
反应条件
5,10,15,20-tetrakis-pentafluorophenyl-21H,23H-porphyrin iron(III) chloride; iodosylbenzene in dichloromethane 20 h; Ambient temperature;
参考文献
Komuro, Masakatsu; Nagatsu, Yoshio; Higuchi, Tsunehiko; Hirobe, Masaaki
Tetrahedron Letters, 1992 , vol. 33, # 34 p. 4949 - 4952
反应条件
(i) LDA, (ii) /BRN= 471308/; Multistep reaction;
参考文献
Creger,P.L.
Journal of the American Chemical Society, 1967 , vol. 89, # 10 p. 2500 - 2501
参考文献
Hudson; Hauser
Journal of the American Chemical Society, 1940 , vol. 62, p. 2459
Journal of the American Chemical Society, 1941 , vol. 63, p. 3161
Full Text Show Details
Rothstein; Saville
Journal of the Chemical Society, 1949 , p. 1946,1949
反应条件
1: 100 percent / LHMDS / -78 - 20 °C
2: 100 percent / 0.5 h / 100 °C
3: 70 percent / 1 M HCl / H2O
View Scheme
参考文献
Shiina, Isamu; Nagasue, Hiroshi
Tetrahedron Letters, 2002 , vol. 43, # 33 p. 5837 - 5840
反应条件
potassium hydroxide in ethylene glycol
参考文献
Costantino,A. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 912 - 920
反应条件
dipotassium hydrogenphosphate; silver carbonate; p-benozquinone; palladium diacetate in tert-butyl alcohol
T=120°C; 3 h;
参考文献
Giri, Ramesh; Maugel, Nathan; Li, Jiao-Jie; Wang, Dong-Hui; Breazzano, Steven P.; Saunders, Lindsey B.; Yu, Jin-Quan
Journal of the American Chemical Society, 2007 , vol. 129, # 12 p. 3510 - 3511
