2,2-二甲基-3-丁烯酸合成路线 （共 12 条）
反应条件
sodium amide; dimethyl sulfoxide T=0 - 50°C;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; RUAH, Sara, Hadida, S.; GROOTENHUIS, Peter, D., J.; VAN GOOR, Fredrick; MILLER, Mark, T.; MCCARTNEY, Jason; ZHOU, Jinglan; BEAR, Brian; NUMA, Mehdi, Michel, Djamel
Patent: WO2010/53471 A1, 2010 ;
Location in patent: Page/Page column 58-60 ;
反应条件
1: NaOH / H2O 2: NaNH2 / dimethylsulfoxide View Scheme
参考文献
Journal of the American Chemical Society, , vol. 97, p. 4825 - 4836
反应条件
1: PCl5, DMF / CH2Cl2 2: NaOH / H2O 3: NaNH2 / dimethylsulfoxide View Scheme
参考文献
Journal of the American Chemical Society, , vol. 97, p. 4825 - 4836
反应条件
magnesium bromide T=-78°C;
参考文献
Bridges, Alexander J.; Fedij, Victor; Turowski, Eugene C.
Journal of the Chemical Society, Chemical Communications, 1983 , # 19 p. 1093 - 1095
反应条件
1: PCl5 2: NaOH 3: 80 percent / NaNH2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 16 p. 3802 - 3806
反应条件
1: NaOH 2: 80 percent / NaNH2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 16 p. 3802 - 3806
反应条件
1.1: hydrogenchloride / water / |Reflux 2.1: magnesium / tetrahydrofuran / 15 - 22 °C 2.2: 1 h 3.1: potassium hydroxide / methanol / 1 h View Scheme
反应条件
1.1: magnesium / tetrahydrofuran / 15 - 22 °C 1.2: 1 h 2.1: potassium hydroxide / methanol / 1 h View Scheme
反应条件
1: t-BuLi / 1 h / -25 °C 2: -78 °C View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 19 p. 1093 - 1095
反应条件
T=-78°C; Yield given. Yields of byproduct given;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 19 p. 1093 - 1095
