4-(4-氯苯基)-1-[3-[2-(4-氟苯基)-1,3-二氧戊环-2-基]丙基]哌啶-4-醇合成路线 （共 6 条）
反应条件
hydrogenchloride in methanol 6 h; Heating;
参考文献
Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334
反应条件
sodium cyanoborohydride; acetic acid in methanol
T=20°C; 30 h;
参考文献
Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide
T=100°C; 17.5 h;
参考文献
Moerlein, Stephen M.; Stoecklin, Gerhard L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1319 - 1324
反应条件
1: 83 percent / p-TsOH / benzene / 20 h / Heating
2: 93 percent / DIBAL-H / CH2Cl2; tetrahydrofuran / 1 h / -78 °C
3: 78 percent / acetic acid; NaCNBH3 / methanol / 30 h / 20 °C
View Scheme
参考文献
Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334
反应条件
1: 93 percent / DIBAL-H / CH2Cl2; tetrahydrofuran / 1 h / -78 °C
2: 78 percent / acetic acid; NaCNBH3 / methanol / 30 h / 20 °C
View Scheme
参考文献
Anjaiah, Siddam; Chandrasekhar, Srivari; Gree, Rene
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 11 p. 1329 - 1334
反应条件
1: p-toluenesulfonic acid / benzene / 12 h / Heating
2: K2CO3, KI / dimethylformamide / 17.5 h / 100 °C
View Scheme
参考文献
Moerlein, Stephen M.; Stoecklin, Gerhard L.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1319 - 1324
