4-氨基-1-(2-脱氧-2-氟-beta-D-阿拉伯呋喃基)-2(1H)-嘧啶酮合成路线 （共 7 条）
反应条件
ammonia in methanol T=20°C; 15 h;
参考文献
Zhengzhou University; Analyse Testing And Research Center Of Henan Province
Patent: EP2177527 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
ammonium hydroxide; hydrogen; palladium on activated charcoal in ethanol P=1034.3 Torr; 2 h;
参考文献
Watanabe; Harada; Zeidler; Matulic-Adamic; Takahashi; Ren; Cheng; Fox; Chou; Zhu; Polsky; Gold; Armstrong
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2145 - 2150
反应条件
triethylamine in methanol 16 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 8 p. 2137 - 2145
反应条件
1: CCl4 / Heating 2: NH3 / methanol / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 713 - 715
反应条件
1: HBr; HOAc 2: CCl4 / Heating 3: NH3 / methanol / 20 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 713 - 715
参考文献
Gilead Sciences, Inc.
Patent: US5672697 A1, 1997 ;
反应条件
2: H2 / 10percent Pd/C / methanol / 4.5 h / 1034.3 Torr
View Scheme
参考文献
Perlman; Watanabe; Schinazi; Fox
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 741 - 748
