2-[(叔丁氧羰基)氨基]-3-萘-2-基丙酸合成路线 （共 4 条）
参考文献
Trivedi; Anson; Steel; Worley
Synlett, 2001 , # 12 p. 1932 - 1934
反应条件
1: benzyl-methyl-amine With ethyl-α,α,α-trifluoroacetate T=0 - 22°C; 0.5 h; 2: (S)-2-[N-(t-butoxycarbonyl)amino]-3-(naphth-2-yl)-propionic acid With 4-methyl-morpholine in ethyl acetate T=-15°C; 0.25 h; 3: isobutyl chloroformate in ethyl acetate T=-15°C; 1 h;
参考文献
Prashad, Mahavir; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J.; Prikoszovich, Walter
Organic Process Research and Development, 1999 , vol. 3, # 6 p. 409 - 415
反应条件
1: (S)-2-[N-(t-butoxycarbonyl)amino]-3-(naphth-2-yl)-propionic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in tetrahydrofuran 0.333333 h; 2: methanol in tetrahydrofuran T=20°C;
参考文献
Conde-Frieboes, Kilian Waldemar; Ankersen, Michael; Sensfuss, Ulrich; Wulff, Birgitte Schjellerup; Thogersen, Henning; Lustenberger, Philipp; Rudolf, Klaus; Krist, Bernd; Muller, Stephan; Stenkamp, Dirk; Schindler, Marcus; Wieland, Heike; Arndt, Kirsten
Patent: US2007/185128 A1, 2007 ;
Location in patent: Page/Page column 27 ;
US 20070185128 A1
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=20°C; 72 h;
参考文献
Nozawa, Dai; Okubo, Taketoshi; Chaki, Shigeyuki; Okuyama, Shigeru; Nakazato, Atsuro
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 8 p. 1232 - 1239
