1,4-二氮杂双环[4.3.0]壬烷合成路线 （共 17 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 1.5 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: US2008/200471 A1, 2008 ;
Location in patent: Page/Page column 37; 37-38 ;
US 20080200471 A1
反应条件
hydrogen; nickel in isopropyl alcohol T=150 - 160°C; P=114000 Torr; 2 h;
参考文献
Likhosherstov, A. M.; Peresada, V. P.; Skoldinov, A. P.
Pharmaceutical Chemistry Journal, 1993 , vol. 27, # 10 p. 716 - 718
Khimiko-Farmatsevticheskii Zhurnal, 1993 , vol. 27, # 10 p. 46 - 48
反应条件
lithium aluminium tetrahydride in diethyl ether 96 h; Heating;
参考文献
Shukla, U. K.; Khanna, J. M.; Sharma, Satyavan; Anand, Nitya; Chatterjee, R. K.; Sen, A. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 7 p. 664 - 668
反应条件
chlorohydroalane in tetrahydrofuran
参考文献
Tetrahedron Letters, , vol. 45, # 24 p. 4657 - 4660
反应条件
1: 85 percent / NH3 / ethanol / 48 h / Ambient temperature 2: 50 percent / LiAlH4 / tetrahydrofuran / 0.25 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 12 p. 1445 - 1448
反应条件
1: 85.3 percent / SOCl2 2: 76.7 percent / Et3N / benzene / 24 h / Ambient temperature 3: 85 percent / NH3 / ethanol / 48 h / Ambient temperature 4: 50 percent / LiAlH4 / tetrahydrofuran / 0.25 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 12 p. 1445 - 1448
反应条件
1: 76.7 percent / Et3N / benzene / 24 h / Ambient temperature 2: 85 percent / NH3 / ethanol / 48 h / Ambient temperature 3: 50 percent / LiAlH4 / tetrahydrofuran / 0.25 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 12 p. 1445 - 1448
反应条件
1: 75 percent / 1) 140 deg C, 45 min, 2) 180 deg C, 30 min 2: 40 percent / LiAlH4 / diethyl ether / 96 h / Heating View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 22, # 7 p. 664 - 668
反应条件
potassium hydroxide; ammonium hydroxide; potassium iodide in ethanol; dichloromethane; water
参考文献
G. D. Searle and Co.
Patent: US4086234 A1, 1978 ;
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide Heating;
参考文献
Shukla, U. K.; Khanna, J. M.; Sharma, Satyavan; Anand, Nitya; Chatterjee, R. K.; Sen, A. B.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 7 p. 664 - 668
