2,3-二甲氧基-5-甲基苯甲酸合成路线 （共 17 条）
反应条件
1: 1) formylation, 2) K2CO3 / 2) DMF, 75 deg C, 4h
2: permanganate
View Scheme
参考文献
Nicoletti, Teresa M.; Raston, Colin L.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 1 p. 133 - 138
反应条件
1: aqueous HCl; toluene; amalgamated zinc
2: glycerol; boric acid / 150 °C / Behandeln des auf 110grad abgekuehlten Reaktionsgemisches mit wss.H2SO4
3: aq. NaOH solution
4: water; potassium permanganate
View Scheme
参考文献
Manske; Ledingham
Canadian Journal of Research, Section B: Chemical Sciences, 1944 , vol. 22, p. 115,123
反应条件
potassium permanganate; water; sodium carbonate
参考文献
Fletcher; Tarbell
Journal of the American Chemical Society, 1943 , vol. 65, p. 1431
反应条件
1: diluted aqueous NaOH
2: water; potassium permanganate; sodium carbonate
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参考文献
Fletcher; Tarbell
Journal of the American Chemical Society, 1943 , vol. 65, p. 1431
反应条件
1: 200 - 230 °C
2: diluted aqueous NaOH
3: water; potassium permanganate; sodium carbonate
View Scheme
参考文献
Fletcher; Tarbell
Journal of the American Chemical Society, 1943 , vol. 65, p. 1431
反应条件
hydrogenchloride
1 h; Heating;
参考文献
Hogberg; Strom; Hall; Ogren
Helvetica Chimica Acta, 1990 , vol. 73, # 2 p. 417 - 425
反应条件
1: SOCl2 / toluene / 2 h / 50 °C
2: CH2Cl2 / 2 h / Ambient temperature
3: 82 percent / SOCl2 / 0.5 h / Ambient temperature
4: 1) 1.6 M BuLi / 1) THF, hexane, -78 deg C, 1 h, 2) -45 deg C, 1.5 h
5: 63 percent / 2 M aq. HCl / 1 h / Heating
View Scheme
参考文献
Hogberg; Strom; Hall; Ogren
Helvetica Chimica Acta, 1990 , vol. 73, # 2 p. 417 - 425
反应条件
1: CH2Cl2 / 2 h / Ambient temperature
2: 82 percent / SOCl2 / 0.5 h / Ambient temperature
3: 1) 1.6 M BuLi / 1) THF, hexane, -78 deg C, 1 h, 2) -45 deg C, 1.5 h
4: 63 percent / 2 M aq. HCl / 1 h / Heating
View Scheme
参考文献
Hogberg; Strom; Hall; Ogren
Helvetica Chimica Acta, 1990 , vol. 73, # 2 p. 417 - 425
反应条件
1: 82 percent / SOCl2 / 0.5 h / Ambient temperature
2: 1) 1.6 M BuLi / 1) THF, hexane, -78 deg C, 1 h, 2) -45 deg C, 1.5 h
3: 63 percent / 2 M aq. HCl / 1 h / Heating
View Scheme
参考文献
Hogberg; Strom; Hall; Ogren
Helvetica Chimica Acta, 1990 , vol. 73, # 2 p. 417 - 425
反应条件
permanganate(VII) ion
参考文献
Nicoletti, Teresa M.; Raston, Colin L.; Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 1 p. 133 - 138
