2-羟基-3,4-二甲氧基苯甲酸合成路线 （共 23 条）
反应条件
boron tribromide in dichloromethane T=-20°C; 0.5 h;
参考文献
ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying
Patent: WO2014/31784 A1, 2014 ;
Location in patent: Paragraph 0408 ;
反应条件
sodium hydroxide in methanol
参考文献
Usuki, Yoshinosuke; Adachi, Noriko; Fujita, Ken-Ichi; Ichimura, Akio; Iio, Hideo; Taniguchi, Makoto
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3319 - 3322
反应条件
1: With n-butyllithium; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane T=-78 - 0°C; 2: With oxygen in tetrahydrofuran; hexane T=0 - 20°C; Further stages.;
参考文献
Tetrahedron, , vol. 64, # 46 p. 10552 - 10557
反应条件
1: With potassium hydroxide; water 20 h; Inert atmosphereReflux; 2: With hydrogenchloride in water
参考文献
Brahmachari; Jash; Gangopadhyay; Sarkar; Laskar; Gorai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008 , vol. 47, # 12 p. 1898 - 1902
参考文献
Monatshefte fuer Chemie, , vol. 25, p. 513
Justus Liebigs Annalen der Chemie, , vol. 340, p. 230
反应条件
1: alkali 2: KOH-solution View Scheme
参考文献
Monatshefte fuer Chemie, , vol. 25, p. 513
参考文献
Journal of the Indian Chemical Society, , vol. 31, p. 194,199
反应条件
1: HCl; diethyl ether / anschliessend Erwaermen mit H2O 2: aqueous NaOH 3: aqueous H2O2 View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 31, p. 194,199
反应条件
2: aqueous NaOH 3: aqueous H2O2 View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 31, p. 194,199
反应条件
1: aqueous NaOH 2: aqueous H2O2 View Scheme
参考文献
Journal of the Indian Chemical Society, , vol. 31, p. 194,199
