Boc-L-beta-高脯氨酸合成路线 (共 9 条)
反应条件
1: With sodium hydroxide; water in methanol 2: With hydrogenchloride; water pH=2;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/76440 A1, 2003 ;
Location in patent: Page/Page column 140 ;
WO 03/076440 A1
反应条件
1: With water; sodium hydroxide in methanol T=100°C; 3 h; 2: With hydrogenchloride in methanol; water pH=4 - 5;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; MARUYAMA, Megumi; KINOMURA, Naoya; NOJIMA, Satoshi; TAKAMURA, Masahiro; KAKIGUCHI, Keisuke; TATAMITANI, Hiroto
Patent: WO2011/111875 A1, 2011 ;
Location in patent: Page/Page column 63 ;
WO 2011/111875 A1
反应条件
silver benzoate in 1,4-dioxane T=70°C; Wolff rearrangement; 6 h;
参考文献
Vasanthakumar, Ganga-Ramu; Patil, Basanagoud S.; Suresh Babu, Vommina V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 18 p. 2087 - 2089
反应条件
sodium hydroxide in acetone T=0 - 20°C; pH=10; 2.25 h;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 12 p. 2571 - 2578
反应条件
Burkholderia cepacia lipase; hydrogenchloride in tetrahydrofuran; phosphate buffer T=25°C; pH=7; 48 h;
参考文献
Tetrahedron Asymmetry, , vol. 15, # 21 p. 3407 - 3412
反应条件
1: iBuOCOCl, NEt3 3: silver benzoate 4: LiOH / dioxane View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 20 p. 3609 - 3610
反应条件
2: silver benzoate 3: LiOH / dioxane View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 20 p. 3609 - 3610
参考文献
Sugano, Yuichi; Katzenellenbogen, John A.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 4 p. 361 - 366
反应条件
chloro-trimethyl-silane
T=20°C; 15 h;
参考文献
NOVARTIS AG; DECHANTSREITER, Michael A.; GROB, Jonathan E.; MAC SWEENEY, Aengus; MILTZ, Wolfgang; RANDL, Stefan; SEDRANI, Richard; SELLNER, Holger; SIROCKIN, Finton; VALEUR, Eric
Patent: WO2013/192345 A1, 2013 ;
Location in patent: Page/Page column 103 ;