4,5-二氢环戊并[b]噻吩-6-酮合成路线 （共 20 条）
反应条件
P2O5; methanesulfonic acid T=20°C; 0.666667 h;
参考文献
Bonini, Bianca Flavia; Capito, Elena; Comes-Franchini, Mauro; Ricci, Alfredo; Bottoni, Andrea; Bernardi, Fernando; Miscione, Gian Pietro; Giordano, Laurent; Cowley, Andrew R.
European Journal of Organic Chemistry, 2004 , # 21 p. 4442 - 4451
反应条件
2,2,6,6-tetramethyl-piperidine; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; tris(4-methylphenyl)-phosphine in toluene T=100°C; 3.5 h;
参考文献
Journal of the American Chemical Society, , vol. 127, # 10 p. 3248 - 3249
反应条件
1.1: BuLi / tetrahydrofuran / 1 h / 0 °C 1.2: 100 percent / tetrahydrofuran / 1 h / 0 °C 2.1: 32 percent / [Rh(cod)2](BF4); P(4-tolyl)3; 2,2,6,6-tetramethylpiperidine / toluene / 3.5 h / 100 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 10 p. 3248 - 3249
反应条件
aluminium trichloride in carbon disulfide Yield given;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 19 p. 2249 - 2250
反应条件
1: Na/Hg 2: so2cL 3: 5 g / AlCl3 / CS2 / rt, 20 h; reflux, 2h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 8 p. 2401 - 2408
反应条件
1: 64 percent / NBS, (PhCOO)2 / benzene / Heating 2: 59 percent / NaH / tetrahydrofuran 3: 70 percent / KOH / H2O / Heating 4: 78 percent / neat (no solvent) / 140 °C 5: 44 percent / P2O5, MeSO3H / 0.67 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 12 p. 4239 - 4246
反应条件
1: 59 percent / NaH / tetrahydrofuran 2: 70 percent / KOH / H2O / Heating 3: 78 percent / neat (no solvent) / 140 °C 4: 44 percent / P2O5, MeSO3H / 0.67 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 12 p. 4239 - 4246
反应条件
1: 78 percent / neat (no solvent) / 140 °C 2: 44 percent / P2O5, MeSO3H / 0.67 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 12 p. 4239 - 4246
反应条件
1: 70 percent / KOH / H2O / Heating 2: 78 percent / neat (no solvent) / 140 °C 3: 44 percent / P2O5, MeSO3H / 0.67 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 12 p. 4239 - 4246
反应条件
1: NBS / CCl4 2: 50 percent / NaH 3: 1.) NaOH; 2.) HCl 4: 200 °C 5: 100 percent / SOCl2 6: 60 percent / AlCl3 7: Zn/CH3COOH View Scheme
参考文献
Journal de Chimie Physique et de Physico-Chimie Biologique, , vol. 86, # 1 p. 93 - 98
