alpha,alpha-二甲基-4-甲氧基苯乙胺盐酸盐合成路线 （共 6 条）
反应条件
hydrogenchloride in 1,4-dioxane; tert-butyl methyl ether
T=0°C; 0.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/77009 A1, 2008 ;
Location in patent: Page/Page column 31-32 ;
WO 2008/077009 A1
反应条件
hydrogenchloride; sodium hydroxide; acetic acid; Adam's catalyst in hydrogen; isopropyl alcohol
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US4276304 A1, 1981 ;
反应条件
hydrogenchloride; sodium nitrite in methanol; water
1.) 5 deg C - room temp., 2.) 3 h, reflux;
参考文献
Leclerc; Decker; Schwartz
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 9 p. 1357 - 1367
反应条件
1: 1.) H2, 2.) HCl / 1.) 10percent Pd/C / 1.) ethanol, 8 h, reflux
2: 82 percent / NaNO2, 37percent HCl / methanol; H2O / 1.) 5 deg C - room temp., 2.) 3 h, reflux
View Scheme
参考文献
Leclerc; Decker; Schwartz
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 9 p. 1357 - 1367
反应条件
1: 74 percent / Na, EtOH / 12 h / Heating
2: 1.) H2, 2.) HCl / 1.) 10percent Pd/C / 1.) ethanol, 8 h, reflux
3: 82 percent / NaNO2, 37percent HCl / methanol; H2O / 1.) 5 deg C - room temp., 2.) 3 h, reflux
View Scheme
参考文献
Leclerc; Decker; Schwartz
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 9 p. 1357 - 1367
反应条件
hydrogenchloride in methanol
参考文献
Buchowiecki, Wieslaw; Grosman-Zjawiona, Zofia; Zjawiony, Jordan
Tetrahedron Letters, 1985 , vol. 26, # 9 p. 1245 - 1248
