sodium hydroxide; dicobalt octacarbonyl; carbon monoxide; N-benzyl-N,N,N-trimethyl-ammonium chloride in toluene T=35°C; P=3800 Torr; 20 h;

Ti(III)-citrate; Tris buffer; tetra(n-butyl)ammonium hydroxide; B12 in ethanol pH=8;

1: trimethylsilyl trifluoromethanesulfonate / hexane / 20 °C / |Inert atmosphere 2: n-butyllithium / cyclohexane; tetrahydrofuran / 3 h / -78 - -30 °C / |Inert atmosphere View Scheme